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Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils.
Heestermans M, Salloum-Asfar S, Streef T, Laghmani EH, Salvatori D, Luken BM, Zeerleder SS, Spronk HMH, Korporaal SJ, Kirchhofer D, Wagenaar GTM, Versteeg HH, Reitsma PH, Renné T, van Vlijmen BJM. Heestermans M, et al. Among authors: kirchhofer d. Blood. 2019 May 9;133(19):2090-2099. doi: 10.1182/blood-2018-06-853762. Epub 2019 Mar 21. Blood. 2019. PMID: 30898865 Free article.
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.
Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, Mackman N. Wang JG, et al. Among authors: kirchhofer d. Blood. 2012 Jun 7;119(23):5543-52. doi: 10.1182/blood-2012-01-402156. Epub 2012 Apr 30. Blood. 2012. PMID: 22547577 Free PMC article.
Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.
Unruh D, Turner K, Srinivasan R, Kocatürk B, Qi X, Chu Z, Aronow BJ, Plas DR, Gallo CA, Kalthoff H, Kirchhofer D, Ruf W, Ahmad SA, Lucas FV, Versteeg HH, Bogdanov VY. Unruh D, et al. Among authors: kirchhofer d. Int J Cancer. 2014 Jan 1;134(1):9-20. doi: 10.1002/ijc.28327. Epub 2013 Jul 27. Int J Cancer. 2014. PMID: 23754313 Free PMC article.
Excess of heme induces tissue factor-dependent activation of coagulation in mice.
Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R. Sparkenbaugh EM, et al. Among authors: kirchhofer d. Haematologica. 2015 Mar;100(3):308-14. doi: 10.3324/haematol.2014.114728. Epub 2015 Jan 16. Haematologica. 2015. PMID: 25596265 Free PMC article.
131 results