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198 results
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Restoration of p53 function leads to tumour regression in vivo.
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Ventura A, et al. Nature. 2007 Feb 8;445(7128):661-5. doi: 10.1038/nature05541. Epub 2007 Jan 24. Nature. 2007. PMID: 17251932
Tumor-suppressor p53: implications for tumor development and prognosis.
Kirsch DG, Kastan MB. Kirsch DG, et al. J Clin Oncol. 1998 Sep;16(9):3158-68. doi: 10.1200/JCO.1998.16.9.3158. J Clin Oncol. 1998. PMID: 9738588 Review.
Future of early detection of lung cancer: the role of mouse models.
Shaw AT, Kirsch DG, Jacks T. Shaw AT, et al. Clin Cancer Res. 2005 Jul 1;11(13 Pt 2):4999s-5003s. doi: 10.1158/1078-0432.CCR-05-9005. Clin Cancer Res. 2005. PMID: 16000603 Review.
Mouse models of human non-small-cell lung cancer: raising the bar.
Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T. Kim CF, et al. Cold Spring Harb Symp Quant Biol. 2005;70:241-50. doi: 10.1101/sqb.2005.70.037. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869760 Review.
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. Kirsch DG, et al. Nat Med. 2007 Aug;13(8):992-7. doi: 10.1038/nm1602. Epub 2007 Aug 5. Nat Med. 2007. PMID: 17676052
Dicer1 functions as a haploinsufficient tumor suppressor.
Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J, Kirsch DG, Golub TR, Jacks T. Kumar MS, et al. Genes Dev. 2009 Dec 1;23(23):2700-4. doi: 10.1101/gad.1848209. Epub 2009 Nov 10. Genes Dev. 2009. PMID: 19903759 Free PMC article.
Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.
Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Mito JK, et al. PLoS One. 2009 Nov 30;4(11):e8075. doi: 10.1371/journal.pone.0008075. PLoS One. 2009. PMID: 19956606 Free PMC article.
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T. Kirsch DG, et al. Science. 2010 Jan 29;327(5965):593-6. doi: 10.1126/science.1166202. Epub 2009 Dec 17. Science. 2010. PMID: 20019247 Free PMC article.
Imaging primary lung cancers in mice to study radiation biology.
Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T. Kirsch DG, et al. Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):973-7. doi: 10.1016/j.ijrobp.2009.11.038. Int J Radiat Oncol Biol Phys. 2010. PMID: 20206017 Free PMC article.
Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice.
Lee CL, Moding EJ, Huang X, Li Y, Woodlief LZ, Rodrigues RC, Ma Y, Kirsch DG. Lee CL, et al. Dis Model Mech. 2012 May;5(3):397-402. doi: 10.1242/dmm.009084. Epub 2011 Dec 22. Dis Model Mech. 2012. PMID: 22228755 Free PMC article.
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