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Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.
Bussey KJ, Chin K, Lababidi S, Reimers M, Reinhold WC, Kuo WL, Gwadry F, Ajay, Kouros-Mehr H, Fridlyand J, Jain A, Collins C, Nishizuka S, Tonon G, Roschke A, Gehlhaus K, Kirsch I, Scudiero DA, Gray JW, Weinstein JN. Bussey KJ, et al. Mol Cancer Ther. 2006 Apr;5(4):853-67. doi: 10.1158/1535-7163.MCT-05-0155. Mol Cancer Ther. 2006. PMID: 16648555 Free PMC article.
The SIL gene is essential for mitotic entry and survival of cancer cells.
Erez A, Castiel A, Trakhtenbrot L, Perelman M, Rosenthal E, Goldstein I, Stettner N, Harmelin A, Eldar-Finkelman H, Campaner S, Kirsch I, Izraeli S. Erez A, et al. Cancer Res. 2007 May 1;67(9):4022-7. doi: 10.1158/0008-5472.CAN-07-0064. Epub 2007 Apr 24. Cancer Res. 2007. PMID: 17456584
Validation of biomarkers to predict response to immunotherapy in cancer: Volume II - clinical validation and regulatory considerations.
Dobbin KK, Cesano A, Alvarez J, Hawtin R, Janetzki S, Kirsch I, Masucci GV, Robbins PB, Selvan SR, Streicher HZ, Zhang J, Butterfield LH, Thurin M. Dobbin KK, et al. J Immunother Cancer. 2016 Nov 15;4:77. doi: 10.1186/s40425-016-0179-0. eCollection 2016. J Immunother Cancer. 2016. PMID: 27891226 Free PMC article. Review.
Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance.
Roschke AV, Glebov OK, Lababidi S, Gehlhaus KS, Weinstein JN, Kirsch IR. Roschke AV, et al. Among authors: kirsch ir. Neoplasia. 2008 Nov;10(11):1222-30. doi: 10.1593/neo.08682. Neoplasia. 2008. PMID: 18953431 Free PMC article.
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