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Interleukin-6: from basic science to medicine--40 years in immunology.
Kishimoto T. Kishimoto T. Annu Rev Immunol. 2005;23:1-21. doi: 10.1146/annurev.immunol.23.021704.115806. Annu Rev Immunol. 2005. PMID: 15771564 Review.
The role and therapeutic targeting of IL-6 in rheumatoid arthritis.
Narazaki M, Tanaka T, Kishimoto T. Narazaki M, et al. Among authors: kishimoto t. Expert Rev Clin Immunol. 2017 Jun;13(6):535-551. doi: 10.1080/1744666X.2017.1295850. Epub 2017 Mar 3. Expert Rev Clin Immunol. 2017. PMID: 28494214 Review.
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.
Nishimoto N, Kanakura Y, Aozasa K, Johkoh T, Nakamura M, Nakano S, Nakano N, Ikeda Y, Sasaki T, Nishioka K, Hara M, Taguchi H, Kimura Y, Kato Y, Asaoku H, Kumagai S, Kodama F, Nakahara H, Hagihara K, Yoshizaki K, Kishimoto T. Nishimoto N, et al. Among authors: kishimoto t. Blood. 2005 Oct 15;106(8):2627-32. doi: 10.1182/blood-2004-12-4602. Epub 2005 Jul 5. Blood. 2005. PMID: 15998837 Clinical Trial.
Humanized anti-interleukin 6 receptor antibody induced long-term remission in a patient with life-threatening refractory autoimmune hemolytic anemia.
Kunitomi A, Konaka Y, Yagita M, Nishimoto N, Kishimoto T, Takatsuki K. Kunitomi A, et al. Among authors: kishimoto t. Int J Hematol. 2004 Oct;80(3):246-9. doi: 10.1532/ijh97.04058. Int J Hematol. 2004. PMID: 15540899
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial.
Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T. Nishimoto N, et al. Among authors: kishimoto t. Arthritis Rheum. 2004 Jun;50(6):1761-9. doi: 10.1002/art.20303. Arthritis Rheum. 2004. PMID: 15188351 Clinical Trial.
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.
Nakahara H, Song J, Sugimoto M, Hagihara K, Kishimoto T, Yoshizaki K, Nishimoto N. Nakahara H, et al. Among authors: kishimoto t. Arthritis Rheum. 2003 Jun;48(6):1521-9. doi: 10.1002/art.11143. Arthritis Rheum. 2003. PMID: 12794819
Synergistic effect on the attenuation of collagen induced arthritis in tumor necrosis factor receptor I (TNFRI) and interleukin 6 double knockout mice.
Yamaguchi N, Ohshima S, Umeshita-Sasai M, Nishioka K, Kobayashi H, Mima T, Kishimoto T, Saeki Y. Yamaguchi N, et al. Among authors: kishimoto t. J Rheumatol. 2003 Jan;30(1):22-7. J Rheumatol. 2003. PMID: 12508385
Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.
Katsume A, Saito H, Yamada Y, Yorozu K, Ueda O, Akamatsu K, Nishimoto N, Kishimoto T, Yoshizaki K, Ohsugi Y. Katsume A, et al. Among authors: kishimoto t. Cytokine. 2002 Dec 21;20(6):304-11. doi: 10.1006/cyto.2002.2012. Cytokine. 2002. PMID: 12633573
Tocilizumab: molecular intervention therapy in children with systemic juvenile idiopathic arthritis.
Yokota S, Kishimoto T. Yokota S, et al. Among authors: kishimoto t. Expert Rev Clin Immunol. 2010 Sep;6(5):735-43. doi: 10.1586/eci.10.41. Expert Rev Clin Immunol. 2010. PMID: 20828281 Review.
Interleukin-6: discovery of a pleiotropic cytokine.
Kishimoto T. Kishimoto T. Arthritis Res Ther. 2006;8 Suppl 2(Suppl 2):S2. doi: 10.1186/ar1916. Epub 2006 Jul 28. Arthritis Res Ther. 2006. PMID: 16899106 Free PMC article. Review.
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