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The G-protein betagamma complex.
Gautam N, Downes GB, Yan K, Kisselev O. Gautam N, et al. Among authors: kisselev o. Cell Signal. 1998 Jul;10(7):447-55. doi: 10.1016/s0898-6568(98)00006-0. Cell Signal. 1998. PMID: 9754712 Review.
Specific interaction with rhodopsin is dependent on the gamma subunit type in a G protein.
Kisselev O, Gautam N. Kisselev O, et al. J Biol Chem. 1993 Nov 25;268(33):24519-22. J Biol Chem. 1993. PMID: 8227005
Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex.
Kisselev O, Pronin A, Ermolaeva M, Gautam N. Kisselev O, et al. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9102-6. doi: 10.1073/pnas.92.20.9102. Proc Natl Acad Sci U S A. 1995. PMID: 7568081 Free PMC article.
Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit.
Kisselev O, Ermolaeva M, Gautam N. Kisselev O, et al. J Biol Chem. 1995 Oct 27;270(43):25356-8. doi: 10.1074/jbc.270.43.25356. J Biol Chem. 1995. PMID: 7592699
Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening.
Taylor CM, Barda Y, Kisselev OG, Marshall GR. Taylor CM, et al. Among authors: kisselev og. J Med Chem. 2008 Sep 11;51(17):5297-303. doi: 10.1021/jm800326q. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707087 Free PMC article.
Alternate binding mode of C-terminal phenethylamine analogs of G(t)alpha(340-350) to photoactivated rhodopsin.
Anderson MA, Ogbay B, Kisselev OG, Cistola DP, Marshall GR. Anderson MA, et al. Among authors: kisselev og. Chem Biol Drug Des. 2006 Dec;68(6):295-307. doi: 10.1111/j.1747-0285.2006.00460.x. Chem Biol Drug Des. 2006. PMID: 17177891
G-protein alpha and beta-gamma subunits interact with conformationally distinct signaling states of rhodopsin.
Downs MA, Arimoto R, Marshall GR, Kisselev OG. Downs MA, et al. Vision Res. 2006 Dec;46(27):4442-8. doi: 10.1016/j.visres.2006.07.021. Epub 2006 Sep 20. Vision Res. 2006. PMID: 16989885 Review.
Rhodopsin-interacting surface of the transducin gamma subunit.
Kisselev OG, Downs MA. Kisselev OG, et al. Biochemistry. 2006 Aug 8;45(31):9386-92. doi: 10.1021/bi060806x. Biochemistry. 2006. PMID: 16878973
Previously, we have shown by high-resolution NMR that the farnesylated C-terminal peptide of Gtgamma(60-71), DKNPFKELKGGC, assumes an amphipathic helical conformation during interaction with metarhodopsin II [Kisselev, O. G., and Downs, M. A. (2003) Structure 11, 36 …
Previously, we have shown by high-resolution NMR that the farnesylated C-terminal peptide of Gtgamma(60-71), DKNPFKELKGGC, assumes an amphip …
Relative strength of cation-pi vs salt-bridge interactions: the Gtalpha(340-350) peptide/rhodopsin system.
Anderson MA, Ogbay B, Arimoto R, Sha W, Kisselev OG, Cistola DP, Marshall GR. Anderson MA, et al. J Am Chem Soc. 2006 Jun 14;128(23):7531-41. doi: 10.1021/ja058513z. J Am Chem Soc. 2006. PMID: 16756308
Conformational changes in the phosphorylated C-terminal domain of rhodopsin during rhodopsin arrestin interactions.
Kisselev OG, Downs MA, McDowell JH, Hargrave PA. Kisselev OG, et al. J Biol Chem. 2004 Dec 3;279(49):51203-7. doi: 10.1074/jbc.M407341200. Epub 2004 Sep 6. J Biol Chem. 2004. PMID: 15351781
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