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Id1 is down-regulated by hepatocyte growth factor via ERK-dependent and ERK-independent signaling pathways, leading to increased expression of p16INK4a in hepatoma cells.
Ushio K, Hashimoto T, Kitamura N, Tanaka T. Ushio K, et al. Mol Cancer Res. 2009 Jul;7(7):1179-88. doi: 10.1158/1541-7786.MCR-08-0289. Epub 2009 Jun 30. Mol Cancer Res. 2009. PMID: 19567783
Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes.
Mizuno E, Iura T, Mukai A, Yoshimori T, Kitamura N, Komada M. Mizuno E, et al. Mol Biol Cell. 2005 Nov;16(11):5163-74. doi: 10.1091/mbc.e05-06-0560. Epub 2005 Aug 24. Mol Biol Cell. 2005. PMID: 16120644 Free PMC article.
TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.
Hashimoto T, Kato M, Shimomura T, Kitamura N. Hashimoto T, et al. FEBS J. 2010 Dec;277(23):4888-900. doi: 10.1111/j.1742-4658.2010.07894.x. Epub 2010 Oct 26. FEBS J. 2010. PMID: 20977675
Type II transmembrane serine proteases (TTSPs) are structurally defined by the presence of a transmembrane domain located near the N-terminus and a C-terminal extracellular serine protease domain. ...
Type II transmembrane serine proteases (TTSPs) are structurally defined by the presence of a transmembrane domain located near the N- …
Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation.
Kondo A, Hirayama N, Sugito Y, Shono M, Tanaka T, Kitamura N. Kondo A, et al. J Biol Chem. 2008 Jan 18;283(3):1428-36. doi: 10.1074/jbc.M704999200. Epub 2007 Nov 14. J Biol Chem. 2008. PMID: 18003605
Inhibitory effect of c-Met mutants on the formation of branching tubules by a porcine aortic endothelial cell line.
Maemura M, Yoshimoto A, Tsukada Y, Morishita Y, Miyazawa K, Tanaka T, Kitamura N. Maemura M, et al. Cancer Sci. 2006 Dec;97(12):1343-50. doi: 10.1111/j.1349-7006.2006.00335.x. Epub 2006 Oct 9. Cancer Sci. 2006. PMID: 17032311
The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A.
Yamasaki A, Tani K, Yamamoto A, Kitamura N, Komada M. Yamasaki A, et al. Mol Biol Cell. 2006 Nov;17(11):4876-87. doi: 10.1091/mbc.e06-05-0444. Epub 2006 Sep 6. Mol Biol Cell. 2006. PMID: 16957052 Free PMC article.
Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.
Han J, Tsukada Y, Hara E, Kitamura N, Tanaka T. Han J, et al. J Biol Chem. 2005 Sep 9;280(36):31548-56. doi: 10.1074/jbc.M503431200. Epub 2005 Jul 13. J Biol Chem. 2005. PMID: 16014626
Enhanced JNK activation by NESK without kinase activity upon caspase-mediated cleavage during apoptosis.
Kakinuma H, Inomata H, Kitamura N. Kakinuma H, et al. Cell Signal. 2005 Nov;17(11):1439-48. doi: 10.1016/j.cellsig.2005.03.004. Cell Signal. 2005. PMID: 15913957
NESK belongs to the germinal center kinase (GCK) family and selectively activates the c-Jun N-terminal kinase (JNK) pathway when overexpressed in cultured cells. ...The cleavage of NESK occurred at two sites, generating three fragments: an N-terminal fragment contai …
NESK belongs to the germinal center kinase (GCK) family and selectively activates the c-Jun N-terminal kinase (JNK) pathway when over …
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