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Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System.
Morán Luengo T, Kityk R, Mayer MP, Rüdiger SGD. Morán Luengo T, et al. Among authors: kityk r. Mol Cell. 2018 May 3;70(3):545-552.e9. doi: 10.1016/j.molcel.2018.03.028. Epub 2018 Apr 26. Mol Cell. 2018. PMID: 29706537 Free article.
Alternative modes of client binding enable functional plasticity of Hsp70.
Mashaghi A, Bezrukavnikov S, Minde DP, Wentink AS, Kityk R, Zachmann-Brand B, Mayer MP, Kramer G, Bukau B, Tans SJ. Mashaghi A, et al. Among authors: kityk r. Nature. 2016 Nov 17;539(7629):448-451. doi: 10.1038/nature20137. Epub 2016 Oct 26. Nature. 2016. PMID: 27783598
Insights into the molecular mechanism of allostery in Hsp70s.
Mayer MP, Kityk R. Mayer MP, et al. Among authors: kityk r. Front Mol Biosci. 2015 Oct 20;2:58. doi: 10.3389/fmolb.2015.00058. eCollection 2015. Front Mol Biosci. 2015. PMID: 26539440 Free PMC article. Review.
The novolactone natural product disrupts the allosteric regulation of Hsp70.
Hassan AQ, Kirby CA, Zhou W, Schuhmann T, Kityk R, Kipp DR, Baird J, Chen J, Chen Y, Chung F, Hoepfner D, Movva NR, Pagliarini R, Petersen F, Quinn C, Quinn D, Riedl R, Schmitt EK, Schitter A, Stams T, Studer C, Fortin PD, Mayer MP, Sadlish H. Hassan AQ, et al. Among authors: kityk r. Chem Biol. 2015 Jan 22;22(1):87-97. doi: 10.1016/j.chembiol.2014.11.007. Epub 2014 Dec 24. Chem Biol. 2015. PMID: 25544045