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A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. Goettsch C, et al. Among authors: kjolby m. Atherosclerosis. 2016 Aug;251:109-118. doi: 10.1016/j.atherosclerosis.2016.06.011. Epub 2016 Jun 9. Atherosclerosis. 2016. PMID: 27318830 Free PMC article.
The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion.
Gustafsen C, Kjolby M, Nyegaard M, Mattheisen M, Lundhede J, Buttenschøn H, Mors O, Bentzon JF, Madsen P, Nykjaer A, Glerup S. Gustafsen C, et al. Among authors: kjolby m. Cell Metab. 2014 Feb 4;19(2):310-8. doi: 10.1016/j.cmet.2013.12.006. Cell Metab. 2014. PMID: 24506872 Free article.
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Goettsch C, et al. Among authors: kjolby m. J Clin Invest. 2016 Apr 1;126(4):1323-36. doi: 10.1172/JCI80851. Epub 2016 Mar 7. J Clin Invest. 2016. PMID: 26950419 Free PMC article.
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Goettsch C, Kjolby M, Aikawa E. Goettsch C, et al. Among authors: kjolby m. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):19-25. doi: 10.1161/ATVBAHA.117.310292. Epub 2017 Nov 30. Arterioscler Thromb Vasc Biol. 2018. PMID: 29191923 Free PMC article. Review.
Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease.
Jankowski V, Saritas T, Kjolby M, Hermann J, Speer T, Himmelsbach A, Mahr K, Heuschkel MA, Schunk SJ, Thirup S, Winther S, Bottcher M, Nyegard M, Nykjaer A, Kramann R, Kaesler N, Jankowski J, Floege J, Marx N, Goettsch C. Jankowski V, et al. Among authors: kjolby m. Kidney Int. 2022 Mar;101(3):574-584. doi: 10.1016/j.kint.2021.10.018. Epub 2021 Nov 9. Kidney Int. 2022. PMID: 34767831 Free article.
58 results