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A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.
Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM. Prabhudesai S, et al. Among authors: klarner fg. Neurotherapeutics. 2012 Apr;9(2):464-76. doi: 10.1007/s13311-012-0105-1. Neurotherapeutics. 2012. PMID: 22373667 Free PMC article.
A molecular tweezer for lysine and arginine.
Fokkens M, Schrader T, Klärner FG. Fokkens M, et al. Among authors: klarner fg. J Am Chem Soc. 2005 Oct 19;127(41):14415-21. doi: 10.1021/ja052806a. J Am Chem Soc. 2005. PMID: 16218636
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. Sinha S, et al. Among authors: klarner fg. J Am Chem Soc. 2011 Oct 26;133(42):16958-69. doi: 10.1021/ja206279b. Epub 2011 Sep 29. J Am Chem Soc. 2011. PMID: 21916458 Free PMC article.
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G. Attar A, et al. Among authors: klarner fg. Brain. 2012 Dec;135(Pt 12):3735-48. doi: 10.1093/brain/aws289. Epub 2012 Nov 26. Brain. 2012. PMID: 23183235 Free PMC article.
Molecular tweezers targeting transthyretin amyloidosis.
Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR. Ferreira N, et al. Among authors: klarner fg. Neurotherapeutics. 2014 Apr;11(2):450-61. doi: 10.1007/s13311-013-0256-8. Neurotherapeutics. 2014. PMID: 24459092 Free PMC article.
Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.
Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ. Acharya S, et al. Among authors: klarner fg. J Biol Chem. 2014 Apr 11;289(15):10727-10737. doi: 10.1074/jbc.M113.524520. Epub 2014 Feb 24. J Biol Chem. 2014. PMID: 24567327 Free PMC article.
85 results