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Influence of cholestasis on absorption of ursodeoxycholic acid
Sauer P, et al. Dig Dis Sci 1999. Among authors: Kloters-Plachky P. PMID 10219843
Absorption of UDCA increased from 39.8 +/- 5.0% to 61.1 +/- 6.2% of the administered dose, indicating an improvement of the absorption rate after decrease of cholestasis by 53.65% (P < 0.05). ...
Absorption of UDCA increased from 39.8 +/- 5.0% to 61.1 +/- 6.2% of the administered dose, indicating an improvement of the absorption rate …
Development of dominant bile duct stenoses in patients with primary sclerosing cholangitis treated with ursodeoxycholic acid: outcome after endoscopic treatment
Stiehl A, et al. J Hepatol 2002 - Clinical Trial. Among authors: Kloters-Plachky P. PMID 11830325
The actuarial survival free of liver transplantation of the whole group at 3, 5 and 7 years were 0.987, 0.935 and 0.891 and the corresponding survival rates predicted with the Mayo multicenter survival model were 0.860, 0.775 and 0.737 (P<0.001). ...
The actuarial survival free of liver transplantation of the whole group at 3, 5 and 7 years were 0.987, 0.935 and 0.891 and the correspondin …
Influence of dominant bile duct stenoses and biliary infections on outcome in primary sclerosing cholangitis
Rudolph G, et al. J Hepatol 2009. Among authors: Kloters-Plachky P. PMID 19410324
Survival free of liver transplantation in patients without dominant stenosis at 18 years was 73.1% and of patients with dominant stenosis was 25.0% (p=0.011). Bacteria in bile had no effect on survival whereas Candida in bile was associated with reduced survival (p=0.025). CONCLUSIONS: In patients with dominant stenosis, survival free of liver transplantation is reduced. ...
Survival free of liver transplantation in patients without dominant stenosis at 18 years was 73.1% and of patients with dominant stenosis wa …
Effect of scheduled endoscopic dilatation of dominant strictures on outcome in patients with primary sclerosing cholangitis
Rupp C, et al. Gut 2019. Among authors: Kloters-Plachky P. PMID 30910856 Free PMC article.
After a mean follow-up of 9.9 years, the rate of transplantation-free survival was higher in patients receiving scheduled ERCP (51% vs 29.3%; p<0.001), as was transplantation-free survival time (median: 17.9 vs 15.2 years; log-rank: p=0.008). ...IBD (p=0.03), DS (p=0.006), higher Mayo Risk Score (p=0.02) and non-adherence to scheduled endoscopy (p=0.005) were independently associated with transplantation-free survival. ...
After a mean follow-up of 9.9 years, the rate of transplantation-free survival was higher in patients receiving scheduled ERCP (51% vs 29.3% …
The MBOAT7 rs641738 variant is associated with an improved outcome in primary sclerosing cholangitis
Freund C, et al. Clin Res Hepatol Gastroenterol 2020. Among authors: Kloters-Plachky P. PMID 31928970
RESULTS: Transplant-free survival was significantly prolonged in carriers of two rs641738 variant alleles, which was referred to as the TT genotype (mean 19.6 years; 95% confidence interval [CI]: 16.3-22.9 years) compared to the CC (mean 15.4 years, 95% CI 12.8-18.0 years) and heterozygous genotypes (mean 13.2 years, 95% CI 11.4-15.0 years) (P=0.017). ...
RESULTS: Transplant-free survival was significantly prolonged in carriers of two rs641738 variant alleles, which was referred to as the TT g …
Downregulation of ileal bile acid absorption in bile-duct-ligated rats
Sauer P, et al. J Hepatol 2000. Among authors: Kloters-Plachky P. PMID 10905579
RESULTS: After bile duct ligation the intestinal absorption rates of taurocholate were lower (p<0.05) and after biliary diversion absorption rates were higher compared to sham-operated animals (p<0.05). ...However, in cholestatic rats, the expression of the 99-kDa dimer of IBAT was decreased compared to controls (p<0.05), whereas the 46-kDa monomeric protein of IBAT and the expression of ILBP was unchanged. ...
RESULTS: After bile duct ligation the intestinal absorption rates of taurocholate were lower (p<0.05) and after biliary diversion …
Effects of increased von Willebrand factor levels on primary hemostasis in thrombocytopenic patients with liver cirrhosis
Wannhoff A, et al. PLoS One 2014. Among authors: Kloters-Plachky P. PMID 25397410 Free PMC article.
Multivariate analysis revealed that hematocrit (P = 0.027) and vWF-antigen levels (P = 0.010) are the predictors of a pathological PFA-100 test in cirrhotic patients. ...In thrombocytopenic (< 150/nL) patients with cirrhosis, normal PFA-100 results were associated with higher vWF-antigen levels (462.3 ± 235.9% vs. 338.7 ± 151.6%, P = 0.021). ...
Multivariate analysis revealed that hematocrit (P = 0.027) and vWF-antigen levels (P = 0.010) are the predictors of a patholog …
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