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Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.
Moreno S, Klar A, Nurse P. Moreno S, et al. Methods Enzymol. 1991;194:795-823. doi: 10.1016/0076-6879(91)94059-l. Methods Enzymol. 1991. PMID: 2005825 No abstract available.
Sap1, a protein that binds to sequences required for mating-type switching, is essential for viability in Schizosaccharomyces pombe.
Arcangioli B, Copeland TD, Klar AJ. Arcangioli B, et al. Mol Cell Biol. 1994 Mar;14(3):2058-65. doi: 10.1128/mcb.14.3.2058. Mol Cell Biol. 1994. PMID: 8114737 Free PMC article.
The recombination event essential for switching is initiated by a site-specific double-strand break at mat1. The switch-activating protein, Sap1, binds in vitro to a mat1 cis-acting site that was shown earlier to be essential for efficient mating-type switching. ... …
The recombination event essential for switching is initiated by a site-specific double-strand break at mat1. The switch-activating pr …
Differentiated parental DNA strands confer developmental asymmetry on daughter cells in fission yeast.
Klar AJ. Klar AJ. Nature. 1987 Apr 2-8;326(6112):466-70. doi: 10.1038/326466a0. Nature. 1987. PMID: 3561486
A molecular analysis suggests that the process of fission yeast mating-type interconversion uses asymmetry of the DNA strands to generate a regular lineage of cellular differentiation....
A molecular analysis suggests that the process of fission yeast mating-type interconversion uses asymmetry of the DNA strands to gene
The yeast mating-type switching mechanism: a memoir.
Klar AJ. Klar AJ. Genetics. 2010 Oct;186(2):443-9. doi: 10.1534/genetics.110.122531. Genetics. 2010. PMID: 20940334 Free PMC article.
Although flattered at the time, I thought that preparation of such an article called for a more seasoned researcher who had benefitted from seeing his contributions stand the test of time. Now realizing that our discovery of the transposition of a mutation from the …
Although flattered at the time, I thought that preparation of such an article called for a more seasoned researcher who had benefitte …
Defining the epigenetic mechanism of asymmetric cell division of Schizosaccharomyces japonicus yeast.
Yu C, Bonaduce MJ, Klar AJ. Yu C, et al. Genetics. 2013 Jan;193(1):85-94. doi: 10.1534/genetics.112.146233. Epub 2012 Nov 12. Genetics. 2013. PMID: 23150598 Free PMC article.
A key question in developmental biology addresses the mechanism of asymmetric cell division. Asymmetry is crucial for generating cellular diversity required for development in multicellular organisms. ...For technical reasons, it is nearly impossible to determine the exist
A key question in developmental biology addresses the mechanism of asymmetric cell division. Asymmetry is crucial for generating cell
Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe.
Yu C, Bonaduce MJ, Klar AJ. Yu C, et al. Genetics. 2012 May;191(1):285-9. doi: 10.1534/genetics.112.138727. Epub 2012 Feb 29. Genetics. 2012. PMID: 22377633 Free PMC article.
A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that
A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fissi
Going in the right direction: mating-type switching of Schizosaccharomyces pombe is controlled by judicious expression of two different swi2 transcripts.
Yu C, Bonaduce MJ, Klar AJ. Yu C, et al. Genetics. 2012 Mar;190(3):977-87. doi: 10.1534/genetics.111.137109. Epub 2011 Dec 29. Genetics. 2012. PMID: 22209903 Free PMC article.
A previously unrecognized, shorter swi2 mRNA, a truncated form of the swi2, was identified, and its expression requires the mat1-Mc function. ...In addition, we implicated a cis-acting DNA sequence in mat2 utilization. Overall, we showed that switching direct
A previously unrecognized, shorter swi2 mRNA, a truncated form of the swi2, was identified, and its expression requires the ma
Mutations in deoxyribonucleotide biosynthesis pathway cause spreading of silencing across heterochromatic barriers at the mating-type region of the fission yeast.
Singh G, Klar AJ. Singh G, et al. Yeast. 2008 Feb;25(2):117-28. doi: 10.1002/yea.1569. Yeast. 2008. PMID: 18030666
We employed a genetic screen to isolate factors whose mutations allowed spreading of heterochromatin across boundary elements. ...
We employed a genetic screen to isolate factors whose mutations allowed spreading of heterochromatin across boundary elements. ...
DNA sequence of the mat2,3 region of Schizosaccharomyces kambucha shares high homology with the corresponding sequence from Sz. pombe.
Singh G, Klar AJ. Singh G, et al. Yeast. 2003 Nov;20(15):1273-8. doi: 10.1002/yea.1042. Yeast. 2003. PMID: 14618565
Sequence similarity is even higher (99.3%) for mating-type cassettes; deduced amino acid sequences of three of the four Mat peptides (Pi, Pc and Mi) are identical between the two species, while the fourth (Mc) has a single amino acid polymorphism. Comparison of the sequenc …
Sequence similarity is even higher (99.3%) for mating-type cassettes; deduced amino acid sequences of three of the four Mat peptides (Pi, Pc …
Biochemical interactions between proteins and mat1 cis-acting sequences required for imprinting in fission yeast.
Lee BS, Grewal SI, Klar AJ. Lee BS, et al. Mol Cell Biol. 2004 Nov;24(22):9813-22. doi: 10.1128/MCB.24.22.9813-9822.2004. Mol Cell Biol. 2004. PMID: 15509785 Free PMC article.
Second, we showed that only Swi1p and Swi3p interact to form a multiprotein complex and that complex formation did not require their binding to a DNA region defined by the smt-0 mutation. Third, we found that the Swi1p-Swi3p complex physically binds to a regi …
Second, we showed that only Swi1p and Swi3p interact to form a multiprotein complex and that complex formation did not require their …
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