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Targeting herpesvirus reliance of the chemokine system.
Rosenkilde MM, Kledal TN. Rosenkilde MM, et al. Curr Drug Targets. 2006 Jan;7(1):103-18. doi: 10.2174/138945006775270259. Curr Drug Targets. 2006. PMID: 16454703 Review.
Epstein-Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor.
Paulsen SJ, Rosenkilde MM, Eugen-Olsen J, Kledal TN. Paulsen SJ, et al. J Virol. 2005 Jan;79(1):536-46. doi: 10.1128/JVI.79.1.536-546.2005. J Virol. 2005. PMID: 15596846 Free PMC article.
Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation.
Fares S, Spiess K, Olesen ETB, Zuo J, Jackson S, Kledal TN, Wills MR, Rosenkilde MM. Fares S, et al. Among authors: kledal tn. mBio. 2019 Jan 15;10(1):e01707-18. doi: 10.1128/mBio.01707-18. mBio. 2019. PMID: 30647152 Free PMC article.
The future of antiviral immunotoxins.
Spiess K, Jakobsen MH, Kledal TN, Rosenkilde MM. Spiess K, et al. Among authors: kledal tn. J Leukoc Biol. 2016 Jun;99(6):911-25. doi: 10.1189/jlb.2MR1015-468R. Epub 2016 Jan 4. J Leukoc Biol. 2016. PMID: 26729815 Review.
Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo.
Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN, Rosenkilde MM. Spiess K, et al. Among authors: kledal tn. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8427-32. doi: 10.1073/pnas.1509392112. Epub 2015 Jun 15. Proc Natl Acad Sci U S A. 2015. PMID: 26080445 Free PMC article.
Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.
Rosenkilde MM, Benned-Jensen T, Andersen H, Holst PJ, Kledal TN, Lüttichau HR, Larsen JK, Christensen JP, Schwartz TW. Rosenkilde MM, et al. Among authors: kledal tn. J Biol Chem. 2006 May 12;281(19):13199-208. doi: 10.1074/jbc.M602245200. Epub 2006 Mar 15. J Biol Chem. 2006. PMID: 16540462 Free article.
High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3.
Rosenkilde MM, Kledal TN, Schwartz TW. Rosenkilde MM, et al. Mol Pharmacol. 2005 Jul;68(1):11-9. doi: 10.1124/mol.105.011239. Epub 2005 Mar 23. Mol Pharmacol. 2005. PMID: 15788740
Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells.
Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Kledal TN, Rosenkilde MM. Spiess K, et al. Among authors: kledal tn. J Immunol Res. 2017;2017:4069260. doi: 10.1155/2017/4069260. Epub 2017 Jan 30. J Immunol Res. 2017. PMID: 28251165 Free PMC article.
Generating substrate bound functional chemokine gradients in vitro.
Hjortø GM, Hansen M, Larsen NB, Kledal TN. Hjortø GM, et al. Among authors: kledal tn. Biomaterials. 2009 Oct;30(29):5305-11. doi: 10.1016/j.biomaterials.2009.06.018. Epub 2009 Jul 3. Biomaterials. 2009. PMID: 19577290
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