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The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis.
Mulder P, van den Hoek AM, Kleemann R. Mulder P, et al. PLoS One. 2017 Jan 11;12(1):e0169740. doi: 10.1371/journal.pone.0169740. eCollection 2017. PLoS One. 2017. PMID: 28076416 Free PMC article.
Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin.
Kleemann R, Princen HM, Emeis JJ, Jukema JW, Fontijn RD, Horrevoets AJ, Kooistra T, Havekes LM. Kleemann R, et al. Circulation. 2003 Sep 16;108(11):1368-74. doi: 10.1161/01.CIR.0000086460.55494.AF. Epub 2003 Aug 25. Circulation. 2003. PMID: 12939225
METHODS AND RESULTS: Two groups of 20 female APOE*3-Leiden mice received either a high-cholesterol diet (HC) or a high-cholesterol diet supplemented with 0.005% (wt/wt) rosuvastatin (HC+R). ...In a separate low-cholesterol (LC) control group, the dietary cholesterol intake …
METHODS AND RESULTS: Two groups of 20 female APOE*3-Leiden mice received either a high-cholesterol diet (HC) or a high-cholesterol diet supp …
Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice.
Verschuren L, Kleemann R, Offerman EH, Szalai AJ, Emeis SJ, Princen HM, Kooistra T. Verschuren L, et al. Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):161-7. doi: 10.1161/01.ATV.0000148866.29829.19. Epub 2004 Oct 28. Arterioscler Thromb Vasc Biol. 2005. PMID: 15514207
HMG-CoA reductase inhibitors: effects on chronic subacute inflammation and onset of atherosclerosis induced by dietary cholesterol.
Kleemann R, Kooistra T. Kleemann R, et al. Curr Drug Targets Cardiovasc Haematol Disord. 2005 Dec;5(6):441-53. doi: 10.2174/156800605774962077. Curr Drug Targets Cardiovasc Haematol Disord. 2005. PMID: 16503864 Review.
Fenofibrate reduces atherogenesis in ApoE*3Leiden mice: evidence for multiple antiatherogenic effects besides lowering plasma cholesterol.
Kooistra T, Verschuren L, de Vries-van der Weij J, Koenig W, Toet K, Princen HM, Kleemann R. Kooistra T, et al. Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2322-30. doi: 10.1161/01.ATV.0000238348.05028.14. Epub 2006 Jul 27. Arterioscler Thromb Vasc Biol. 2006. PMID: 16873727
Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis.
Kleemann R, Verschuren L, van Erk MJ, Nikolsky Y, Cnubben NH, Verheij ER, Smilde AK, Hendriks HF, Zadelaar S, Smith GJ, Kaznacheev V, Nikolskaya T, Melnikov A, Hurt-Camejo E, van der Greef J, van Ommen B, Kooistra T. Kleemann R, et al. Genome Biol. 2007;8(9):R200. doi: 10.1186/gb-2007-8-9-r200. Genome Biol. 2007. PMID: 17892536 Free PMC article.
Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice.
Westerterp M, Berbée JF, Pires NM, van Mierlo GJ, Kleemann R, Romijn JA, Havekes LM, Rensen PC. Westerterp M, et al. Circulation. 2007 Nov 6;116(19):2173-81. doi: 10.1161/CIRCULATIONAHA.107.693382. Epub 2007 Oct 22. Circulation. 2007. PMID: 17967778
LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms.
Verschuren L, de Vries-van der Weij J, Zadelaar S, Kleemann R, Kooistra T. Verschuren L, et al. J Lipid Res. 2009 Feb;50(2):301-11. doi: 10.1194/jlr.M800374-JLR200. Epub 2008 Aug 30. J Lipid Res. 2009. PMID: 18757914
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.
Verschuren L, Kooistra T, Bernhagen J, Voshol PJ, Ouwens DM, van Erk M, de Vries-van der Weij J, Leng L, van Bockel JH, van Dijk KW, Fingerle-Rowson G, Bucala R, Kleemann R. Verschuren L, et al. Circ Res. 2009 Jul 2;105(1):99-107. doi: 10.1161/CIRCRESAHA.109.199166. Epub 2009 May 28. Circ Res. 2009. PMID: 19478200 Free PMC article.
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