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149 results

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PDX-derived organoids model in vivo drug response and secrete biomarkers.
Huang L, Bockorny B, Paul I, Akshinthala D, Frappart PO, Gandarilla O, Bose A, Sanchez-Gonzalez V, Rouse EE, Lehoux SD, Pandell N, Lim CM, Clohessy JG, Grossman J, Gonzalez R, Del Pino SP, Daaboul G, Sawhney MS, Freedman SD, Kleger A, Cummings RD, Emili A, Muthuswamy LB, Hidalgo M, Muthuswamy SK. Huang L, et al. Among authors: kleger a. JCI Insight. 2020 Nov 5;5(21):e135544. doi: 10.1172/jci.insight.135544. JCI Insight. 2020. PMID: 32990680 Free PMC article.
Pancreatic cancer-derived organoids - a disease modeling tool to predict drug response.
Frappart PO, Walter K, Gout J, Beutel AK, Morawe M, Arnold F, Breunig M, Barth TF, Marienfeld R, Schulte L, Ettrich T, Hackert T, Svinarenko M, Rösler R, Wiese S, Wiese H, Perkhofer L, Müller M, Lechel A, Sainz B Jr, Hermann PC, Seufferlein T, Kleger A. Frappart PO, et al. Among authors: kleger a. United European Gastroenterol J. 2020 Jun;8(5):594-606. doi: 10.1177/2050640620905183. Epub 2020 Feb 19. United European Gastroenterol J. 2020. PMID: 32213029 Free PMC article.
Organoidomics - falling star or new galaxy in pancreatic cancer?
Seufferlein T, Kleger A. Seufferlein T, et al. Among authors: kleger a. Nat Rev Gastroenterol Hepatol. 2018 Oct;15(10):586-587. doi: 10.1038/s41575-018-0052-3. Nat Rev Gastroenterol Hepatol. 2018. PMID: 30046146 No abstract available.
Importance of organoids for personalized medicine.
Perkhofer L, Frappart PO, Müller M, Kleger A. Perkhofer L, et al. Among authors: kleger a. Per Med. 2018 Nov;15(6):461-465. doi: 10.2217/pme-2018-0071. Epub 2018 Nov 12. Per Med. 2018. PMID: 30418092 Review.
An Immunological Glance on Pancreatic Ductal Adenocarcinoma.
Melzer MK, Arnold F, Stifter K, Zengerling F, Azoitei N, Seufferlein T, Bolenz C, Kleger A. Melzer MK, et al. Among authors: kleger a. Int J Mol Sci. 2020 May 8;21(9):3345. doi: 10.3390/ijms21093345. Int J Mol Sci. 2020. PMID: 32397303 Free PMC article. Review.
RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer.
Arnold F, Gout J, Wiese H, Weissinger SE, Roger E, Perkhofer L, Walter K, Scheible J, Prelli Bozzo C, Lechel A, Ettrich TJ, Azoitei N, Hao L, Fürstberger A, Kaminska EK, Sparrer KMJ, Rasche V, Wiese S, Kestler HA, Möller P, Seufferlein T, Frappart PO, Kleger A. Arnold F, et al. Among authors: kleger a. Cancer Res. 2021 Apr 1;81(7):1758-1774. doi: 10.1158/0008-5472.CAN-20-2633. Epub 2021 Feb 2. Cancer Res. 2021. PMID: 33531371
Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.
Breunig M, Merkle J, Wagner M, Melzer MK, Barth TFE, Engleitner T, Krumm J, Wiedenmann S, Cohrs CM, Perkhofer L, Jain G, Krüger J, Hermann PC, Schmid M, Madácsy T, Varga Á, Griger J, Azoitei N, Müller M, Wessely O, Robey PG, Heller S, Dantes Z, Reichert M, Günes C, Bolenz C, Kuhn F, Maléth J, Speier S, Liebau S, Sipos B, Kuster B, Seufferlein T, Rad R, Meier M, Hohwieler M, Kleger A. Breunig M, et al. Among authors: kleger a. Cell Stem Cell. 2021 Jun 3;28(6):1105-1124.e19. doi: 10.1016/j.stem.2021.03.005. Epub 2021 Apr 28. Cell Stem Cell. 2021. PMID: 33915078 Free PMC article.
A Prospective Feasibility Trial to Challenge Patient-Derived Pancreatic Cancer Organoids in Predicting Treatment Response.
Beutel AK, Schütte L, Scheible J, Roger E, Müller M, Perkhofer L, Kestler AMTU, Kraus JM, Kestler HA, Barth TFE, Lemke J, Kornmann M, Ettrich TJ, Gout J, Seufferlein T, Kleger A. Beutel AK, et al. Among authors: kleger a. Cancers (Basel). 2021 May 21;13(11):2539. doi: 10.3390/cancers13112539. Cancers (Basel). 2021. PMID: 34064221 Free PMC article.
149 results