Klein K - Search Results

1

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance.

Zanger UM, Klein K. Zanger UM, et al. Among authors: klein k. Front Genet. 2013 Mar 5;4:24. doi: 10.3389/fgene.2013.00024. eCollection 2013. Front Genet. 2013. PMID: 23467454 Free PMC article.

2

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Lang T, Klein K, Fischer J, Nüssler AK, Neuhaus P, Hofmann U, Eichelbaum M, Schwab M, Zanger UM. Lang T, et al. Among authors: klein k. Pharmacogenetics. 2001 Jul;11(5):399-415. doi: 10.1097/00008571-200107000-00004. Pharmacogenetics. 2001. PMID: 11470993

3

Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction.

Endrizzi K, Fischer J, Klein K, Schwab M, Nüssler A, Neuhaus P, Eichelbaum M, Zanger UM. Endrizzi K, et al. Among authors: klein k. Anal Biochem. 2002 Jan 15;300(2):121-31. doi: 10.1006/abio.2001.5453. Anal Biochem. 2002. PMID: 11779102

4

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.

Burk O, Tegude H, Koch I, Hustert E, Wolbold R, Glaeser H, Klein K, Fromm MF, Nuessler AK, Neuhaus P, Zanger UM, Eichelbaum M, Wojnowski L. Burk O, et al. Among authors: klein k. J Biol Chem. 2002 Jul 5;277(27):24280-8. doi: 10.1074/jbc.M202345200. Epub 2002 Apr 8. J Biol Chem. 2002. PMID: 11940601

5

The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.

Coller JK, Krebsfaenger N, Klein K, Endrizzi K, Wolbold R, Lang T, Nüssler A, Neuhaus P, Zanger UM, Eichelbaum M, Mürdter TE. Coller JK, et al. Among authors: klein k. Br J Clin Pharmacol. 2002 Aug;54(2):157-67. doi: 10.1046/j.1365-2125.2002.01614.x. Br J Clin Pharmacol. 2002. PMID: 12207635 Free PMC article.

6

Detection of single nucleotide polymorphisms in CYP2B6 gene.

Zanger UM, Fischer J, Klein K, Lang T. Zanger UM, et al. Among authors: klein k. Methods Enzymol. 2002;357:45-53. doi: 10.1016/s0076-6879(02)57664-3. Methods Enzymol. 2002. PMID: 12424896 No abstract available.

7

Sex is a major determinant of CYP3A4 expression in human liver.

Wolbold R, Klein K, Burk O, Nüssler AK, Neuhaus P, Eichelbaum M, Schwab M, Zanger UM. Wolbold R, et al. Among authors: klein k. Hepatology. 2003 Oct;38(4):978-88. doi: 10.1053/jhep.2003.50393. Hepatology. 2003. PMID: 14512885

8

A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

Raimundo S, Toscano C, Klein K, Fischer J, Griese EU, Eichelbaum M, Schwab M, Zanger UM. Raimundo S, et al. Among authors: klein k. Clin Pharmacol Ther. 2004 Aug;76(2):128-38. doi: 10.1016/j.clpt.2004.04.009. Clin Pharmacol Ther. 2004. PMID: 15289790

9

A natural CYP2B6 TATA box polymorphism (-82T--> C) leading to enhanced transcription and relocation of the transcriptional start site.

Zukunft J, Lang T, Richter T, Hirsch-Ernst KI, Nussler AK, Klein K, Schwab M, Eichelbaum M, Zanger UM. Zukunft J, et al. Among authors: klein k. Mol Pharmacol. 2005 May;67(5):1772-82. doi: 10.1124/mol.104.008086. Epub 2005 Feb 18. Mol Pharmacol. 2005. PMID: 15722458

10

Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz.

Klein K, Lang T, Saussele T, Barbosa-Sicard E, Schunck WH, Eichelbaum M, Schwab M, Zanger UM. Klein K, et al. Pharmacogenet Genomics. 2005 Dec;15(12):861-73. doi: 10.1097/01213011-200512000-00004. Pharmacogenet Genomics. 2005. PMID: 16272958

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