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A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
Jäschke H, Neumann S, Moore S, Thomas CJ, Colson AO, Costanzi S, Kleinau G, Jiang JK, Paschke R, Raaka BM, Krause G, Gershengorn MC. Jäschke H, et al. Among authors: kleinau g. J Biol Chem. 2006 Apr 14;281(15):9841-4. doi: 10.1074/jbc.C600014200. Epub 2006 Feb 16. J Biol Chem. 2006. PMID: 16488885 Free article.
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.
Moore S, Jaeschke H, Kleinau G, Neumann S, Costanzi S, Jiang JK, Childress J, Raaka BM, Colson A, Paschke R, Krause G, Thomas CJ, Gershengorn MC. Moore S, et al. Among authors: kleinau g. J Med Chem. 2006 Jun 29;49(13):3888-96. doi: 10.1021/jm060247s. J Med Chem. 2006. PMID: 16789744 Free PMC article.
118 results