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Pharmacokinetics and safety of candesartan cilexetil in subjects with normal and impaired liver function.
Hoogkamer JF, Kleinbloesem CH, Ouwerkerk M, Högemann A, Nokhodian A, Kirch W, Weidekamm E. Hoogkamer JF, et al. Among authors: kleinbloesem ch. Eur J Clin Pharmacol. 1998 Jun;54(4):341-5. doi: 10.1007/s002280050471. Eur J Clin Pharmacol. 1998. PMID: 9696961 Clinical Trial.
The effect of oral cilazapril and prazosin on the constrictor effects of locally infused angiotensin I and noradrenaline in human dorsal hand veins.
Belz GG, Beermann C, Schloos J, Kleinbloesem CH. Belz GG, et al. Br J Clin Pharmacol. 1989 Nov;28(5):608-11. doi: 10.1111/j.1365-2125.1989.tb03550.x. Br J Clin Pharmacol. 1989. PMID: 2531608 Free PMC article. Clinical Trial.
Nifedipine: kinetics and dynamics in healthy subjects.
Kleinbloesem CH, van Brummelen P, van de Linde JA, Voogd PJ, Breimer DD. Kleinbloesem CH, et al. Clin Pharmacol Ther. 1984 Jun;35(6):742-9. doi: 10.1038/clpt.1984.105. Clin Pharmacol Ther. 1984. PMID: 6734025
Nifedipine kinetics and dynamics during rectal infusion to steady state with an osmotic system.
Kleinbloesem CH, van Harten J, de Leede LG, van Brummelen P, Breimer DD. Kleinbloesem CH, et al. Clin Pharmacol Ther. 1984 Sep;36(3):396-401. doi: 10.1038/clpt.1984.194. Clin Pharmacol Ther. 1984. PMID: 6467800 Clinical Trial.
Nifedipine: influence of renal function on pharmacokinetic/hemodynamic relationship.
Kleinbloesem CH, van Brummelen P, van Harten J, Danhof M, Breimer DD. Kleinbloesem CH, et al. Clin Pharmacol Ther. 1985 May;37(5):563-74. doi: 10.1038/clpt.1985.89. Clin Pharmacol Ther. 1985. PMID: 3987180 Clinical Trial.
Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans.
Kleinbloesem CH, van Brummelen P, Danhof M, Faber H, Urquhart J, Breimer DD. Kleinbloesem CH, et al. Clin Pharmacol Ther. 1987 Jan;41(1):26-30. doi: 10.1038/clpt.1987.5. Clin Pharmacol Ther. 1987. PMID: 3802702
Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration.
Kleinbloesem CH, van Harten J, Wilson JP, Danhof M, van Brummelen P, Breimer DD. Kleinbloesem CH, et al. Clin Pharmacol Ther. 1986 Jul;40(1):21-8. doi: 10.1038/clpt.1986.134. Clin Pharmacol Ther. 1986. PMID: 3720176 Clinical Trial.
Interactions between cilazapril and propranolol in man; plasma drug concentrations, hormone and enzyme responses, haemodynamics, agonist dose-effect curves and baroreceptor reflex.
Belz GG, Essig J, Kleinbloesem CH, Hoogkamer JF, Wiegand UW, Wellstein A. Belz GG, et al. Br J Clin Pharmacol. 1988 Nov;26(5):547-56. doi: 10.1111/j.1365-2125.1988.tb05294.x. Br J Clin Pharmacol. 1988. PMID: 2974715 Free PMC article. Clinical Trial.
Hemodynamic effects of Ro 23-6152 in patients with essential hypertension.
Folkers HB, van Zwienen JC, Boer P, Kleinbloesem CH, Geyskes GG. Folkers HB, et al. Eur J Clin Pharmacol. 1991;41(4):307-11. doi: 10.1007/BF00314957. Eur J Clin Pharmacol. 1991. PMID: 1804644 Clinical Trial.
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