Kleinjans JC - Search Results

1

Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells.

Hebels DG, Briedé JJ, Khampang R, Kleinjans JC, de Kok TM. Hebels DG, et al. Among authors: kleinjans jc. Toxicol Sci. 2010 Jul;116(1):194-205. doi: 10.1093/toxsci/kfq121. Epub 2010 Apr 19. Toxicol Sci. 2010. PMID: 20403970

2

Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.

Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R. Yildirimman R, et al. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27. Toxicol Sci. 2011. PMID: 21873647 Free PMC article.

3

Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling.

Verheijen M, Schrooders Y, Gmuender H, Nudischer R, Clayton O, Hynes J, Niederer S, Cordes H, Kuepfer L, Kleinjans J, Caiment F. Verheijen M, et al. Toxicol Lett. 2018 Sep 15;294:184-192. doi: 10.1016/j.toxlet.2018.05.029. Epub 2018 May 24. Toxicol Lett. 2018. PMID: 29803840

4

Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study.

Souza TM, Rieswijk L, Beucken TV, Kleinjans J, Jennen D. Souza TM, et al. Toxicology. 2017 Jan 15;375:58-63. doi: 10.1016/j.tox.2016.10.009. Epub 2016 Oct 17. Toxicology. 2017. PMID: 27765683

5

Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data.

Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V. Doktorova TY, et al. Arch Toxicol. 2012 Nov;86(11):1703-15. doi: 10.1007/s00204-012-0946-8. Epub 2012 Sep 28. Arch Toxicol. 2012. PMID: 23052194

6

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.

Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V. Doktorova TY, et al. Arch Toxicol. 2012 Sep;86(9):1399-411. doi: 10.1007/s00204-012-0847-x. Epub 2012 Apr 8. Arch Toxicol. 2012. PMID: 22484513

7

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.

Herwig R, Gmuender H, Corvi R, Bloch KM, Brandenburg A, Castell J, Ceelen L, Chesne C, Doktorova TY, Jennen D, Jennings P, Limonciel A, Lock EA, McMorrow T, Phrakonkham P, Radford R, Slattery C, Stierum R, Vilardell M, Wittenberger T, Yildirimman R, Ryan M, Rogiers V, Kleinjans J. Herwig R, et al. Arch Toxicol. 2016 Sep;90(9):2215-2229. doi: 10.1007/s00204-015-1617-3. Epub 2015 Nov 2. Arch Toxicol. 2016. PMID: 26525393

8

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Among authors: kleinjans jc. Toxicol Sci. 2009 Feb;107(2):544-52. doi: 10.1093/toxsci/kfn237. Epub 2008 Nov 12. Toxicol Sci. 2009. PMID: 19008212

9

Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests.

Theunissen PT, Pennings JL, van Dartel DA, Robinson JF, Kleinjans JC, Piersma AH. Theunissen PT, et al. Among authors: kleinjans jc. Toxicol Sci. 2013 Mar;132(1):118-30. doi: 10.1093/toxsci/kfs333. Epub 2012 Dec 13. Toxicol Sci. 2013. PMID: 23243006

10

Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn).

Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH. Theunissen PT, et al. Among authors: kleinjans jc. Toxicol Sci. 2012 Feb;125(2):430-8. doi: 10.1093/toxsci/kfr293. Epub 2011 Nov 1. Toxicol Sci. 2012. PMID: 22045034

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