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Translational regulation is a key determinant of the cellular response to benzo[a]pyrene.
Smit E, Caiment F, Piepers J, Kleinjans JCS, van den Beucken T. Smit E, et al. Among authors: kleinjans jcs. Toxicol Lett. 2018 Oct 1;295:144-152. doi: 10.1016/j.toxlet.2018.06.009. Epub 2018 Jun 12. Toxicol Lett. 2018. PMID: 29906497
Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling.
Verheijen M, Schrooders Y, Gmuender H, Nudischer R, Clayton O, Hynes J, Niederer S, Cordes H, Kuepfer L, Kleinjans J, Caiment F. Verheijen M, et al. Among authors: kleinjans j. Toxicol Lett. 2018 Sep 15;294:184-192. doi: 10.1016/j.toxlet.2018.05.029. Epub 2018 May 24. Toxicol Lett. 2018. PMID: 29803840
Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study.
Souza TM, Rieswijk L, Beucken TV, Kleinjans J, Jennen D. Souza TM, et al. Among authors: kleinjans j. Toxicology. 2017 Jan 15;375:58-63. doi: 10.1016/j.tox.2016.10.009. Epub 2016 Oct 17. Toxicology. 2017. PMID: 27765683
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J. Kuepfer L, et al. Among authors: kleinjans j. Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. Arch Toxicol. 2018. PMID: 28852801 Free PMC article. No abstract available.
Assessing compound carcinogenicity in vitro using connectivity mapping.
Caiment F, Tsamou M, Jennen D, Kleinjans J. Caiment F, et al. Among authors: kleinjans j. Carcinogenesis. 2014 Jan;35(1):201-7. doi: 10.1093/carcin/bgt278. Epub 2013 Aug 12. Carcinogenesis. 2014. PMID: 23940306
Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.
Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V. Doktorova TY, et al. Among authors: kleinjans j. Arch Toxicol. 2012 Sep;86(9):1399-411. doi: 10.1007/s00204-012-0847-x. Epub 2012 Apr 8. Arch Toxicol. 2012. PMID: 22484513
Data on novel DNA methylation changes induced by valproic acid in human hepatocytes.
Wolters J, van Breda S, Claessen S, de Kok T, Kleinjans J. Wolters J, et al. Among authors: kleinjans j. Data Brief. 2017 Nov 10;16:161-171. doi: 10.1016/j.dib.2017.11.031. eCollection 2018 Feb. Data Brief. 2017. PMID: 29201983 Free PMC article.
Assessment of the anticarcinogenic potential of raw garlic in humans.
Hageman G, Krul C, van Herwijnen M, Schilderman P, Kleinjans J. Hageman G, et al. Among authors: kleinjans j. Cancer Lett. 1997 Mar 19;114(1-2):161-2. doi: 10.1016/s0304-3835(97)04649-1. Cancer Lett. 1997. PMID: 9103278 Clinical Trial. No abstract available.
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.
Herwig R, Gmuender H, Corvi R, Bloch KM, Brandenburg A, Castell J, Ceelen L, Chesne C, Doktorova TY, Jennen D, Jennings P, Limonciel A, Lock EA, McMorrow T, Phrakonkham P, Radford R, Slattery C, Stierum R, Vilardell M, Wittenberger T, Yildirimman R, Ryan M, Rogiers V, Kleinjans J. Herwig R, et al. Among authors: kleinjans j. Arch Toxicol. 2016 Sep;90(9):2215-2229. doi: 10.1007/s00204-015-1617-3. Epub 2015 Nov 2. Arch Toxicol. 2016. PMID: 26525393
Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity.
Rieswijk L, Brauers KJ, Coonen ML, Jennen DG, van Breda SG, Kleinjans JC. Rieswijk L, et al. Among authors: kleinjans jc. Mutagenesis. 2016 Sep;31(5):603-15. doi: 10.1093/mutage/gew027. Epub 2016 Jun 23. Mutagenesis. 2016. PMID: 27338304
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