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Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.
Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT. Ernst MB, et al. Among authors: kleinridders a. J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009. J Neurosci. 2009. PMID: 19759305 Free PMC article.
CNS-targets in control of energy and glucose homeostasis.
Kleinridders A, Könner AC, Brüning JC. Kleinridders A, et al. Curr Opin Pharmacol. 2009 Dec;9(6):794-804. doi: 10.1016/j.coph.2009.10.006. Epub 2009 Oct 31. Curr Opin Pharmacol. 2009. PMID: 19884043 Review.
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.
Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC. Bailly-Maitre B, et al. Among authors: kleinridders a. J Biol Chem. 2010 Feb 26;285(9):6198-207. doi: 10.1074/jbc.M109.056648. Epub 2009 Dec 7. J Biol Chem. 2010. PMID: 19996103 Free PMC article.
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.
Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M. Yazdanpanah B, et al. Among authors: kleinridders a. Nature. 2009 Aug 27;460(7259):1159-63. doi: 10.1038/nature08206. Epub 2009 Jul 29. Nature. 2009. PMID: 19641494
51 results