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Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis.
David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R. David DJ, et al. Among authors: klemenhagen kc. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48. doi: 10.1124/jpet.106.109678. Epub 2007 Jan 19. J Pharmacol Exp Ther. 2007. PMID: 17237257