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Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies.
Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB. Mehta D, et al. Among authors: klengel t. Arch Gen Psychiatry. 2011 Sep;68(9):901-10. doi: 10.1001/archgenpsychiatry.2011.50. Epub 2011 May 2. Arch Gen Psychiatry. 2011. PMID: 21536970 Free PMC article.
Genome-wide association study of antidepressant treatment-emergent suicidal ideation.
Menke A, Domschke K, Czamara D, Klengel T, Hennings J, Lucae S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Binder EB. Menke A, et al. Among authors: klengel t. Neuropsychopharmacology. 2012 Feb;37(3):797-807. doi: 10.1038/npp.2011.257. Epub 2011 Oct 26. Neuropsychopharmacology. 2012. PMID: 22030708 Free PMC article.
Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients.
Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Menke A, et al. Among authors: klengel t. Neuropsychopharmacology. 2012 May;37(6):1455-64. doi: 10.1038/npp.2011.331. Epub 2012 Jan 11. Neuropsychopharmacology. 2012. PMID: 22237309 Free PMC article.
Epigenetics, depression and antidepressant treatment.
Menke A, Klengel T, Binder EB. Menke A, et al. Among authors: klengel t. Curr Pharm Des. 2012;18(36):5879-89. doi: 10.2174/138161212803523590. Curr Pharm Des. 2012. PMID: 22681167 Review.
Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.
Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, Uhr M, Dose T, Unschuld PG, Zihl J, Binder E, Müller-Myhsok B, Holsboer F, Lucae S. Kloiber S, et al. Among authors: klengel t. Eur Neuropsychopharmacol. 2013 Jul;23(7):653-62. doi: 10.1016/j.euroneuro.2012.08.010. Epub 2012 Sep 29. Eur Neuropsychopharmacol. 2013. PMID: 23026132 Free PMC article.
Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.
Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, Binder EB. Klengel T, et al. Nat Neurosci. 2013 Jan;16(1):33-41. doi: 10.1038/nn.3275. Epub 2012 Dec 2. Nat Neurosci. 2013. PMID: 23201972 Free PMC article.
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