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What has prevented the expansion of insulin sensitisers?
Colca JR, Kletzien RF. Colca JR, et al. Expert Opin Investig Drugs. 2006 Mar;15(3):205-10. doi: 10.1517/13543784.15.3.205. Expert Opin Investig Drugs. 2006. PMID: 16503758 Review.
Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins.
Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF. Colca JR, et al. Among authors: Kletzien RF. PLoS One. 2013 May 15;8(5):e61551. doi: 10.1371/journal.pone.0061551. Print 2013. PLoS One. 2013. PMID: 23690925 Free PMC article.
Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor ╬│-sparing thiazolidinedione.
Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, McDonald WG, Colca JR, Kletzien RF, Finck BN. Chen Z, et al. Among authors: Kletzien RF. J Biol Chem. 2012 Jul 6;287(28):23537-48. doi: 10.1074/jbc.M112.363960. Epub 2012 May 23. J Biol Chem. 2012. PMID: 22621923 Free PMC article.
PPAR╬│-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.
Tanis SP, Colca JR, Parker TT, Artman GD 3rd, Larsen SD, McDonald WG, Gadwood RC, Kletzien RF, Zeller JB, Lee PH, Adams WJ. Tanis SP, et al. Among authors: Kletzien RF. Bioorg Med Chem. 2018 Dec 1;26(22):5870-5884. doi: 10.1016/j.bmc.2018.10.033. Epub 2018 Nov 2. Bioorg Med Chem. 2018. PMID: 30429097 No abstract available.
Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.
Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN. Vigueira PA, et al. Among authors: Kletzien RF. Cell Rep. 2014 Jun 26;7(6):2042-2053. doi: 10.1016/j.celrep.2014.05.017. Epub 2014 Jun 5. Cell Rep. 2014. PMID: 24910426 Free PMC article.
The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism.
Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN. Vigueira PA, et al. Among authors: Kletzien RF. Exp Physiol. 2017 Aug 1;102(8):985-999. doi: 10.1113/EP086380. Epub 2017 Jul 10. Exp Physiol. 2017. PMID: 28597936 Free PMC article.
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