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Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart.
Vidal R, Wagner JUG, Braeuning C, Fischer C, Patrick R, Tombor L, Muhly-Reinholz M, John D, Kliem M, Conrad T, Guimarães-Camboa N, Harvey R, Dimmeler S, Sauer S. Vidal R, et al. Among authors: kliem m. JCI Insight. 2019 Nov 14;4(22):e131092. doi: 10.1172/jci.insight.131092. JCI Insight. 2019. PMID: 31723062 Free PMC article.
Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells.
Fischer C, Metsger M, Bauch S, Vidal R, Böttcher M, Grote P, Kliem M, Sauer S. Fischer C, et al. Among authors: kliem m. Sci Signal. 2019 May 14;12(581):eaao5820. doi: 10.1126/scisignal.aao5820. Sci Signal. 2019. PMID: 31088978
Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress.
Plauth A, Geikowski A, Cichon S, Wowro SJ, Liedgens L, Rousseau M, Weidner C, Fuhr L, Kliem M, Jenkins G, Lotito S, Wainwright LJ, Sauer S. Plauth A, et al. Among authors: kliem m. Free Radic Biol Med. 2016 Oct;99:608-622. doi: 10.1016/j.freeradbiomed.2016.08.006. Epub 2016 Aug 8. Free Radic Biol Med. 2016. PMID: 27515816 Free article.
Data of oxygen- and pH-dependent oxidation of resveratrol.
Plauth A, Geikowski A, Cichon S, Wowro SJ, Liedgens L, Rousseau M, Weidner C, Fuhr L, Kliem M, Jenkins G, Lotito S, Wainwright LJ, Sauer S. Plauth A, et al. Among authors: kliem m. Data Brief. 2016 Sep 15;9:433-437. doi: 10.1016/j.dib.2016.09.012. eCollection 2016 Dec. Data Brief. 2016. PMID: 27699197 Free PMC article.
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.
Weidner C, Rousseau M, Micikas RJ, Fischer C, Plauth A, Wowro SJ, Siems K, Hetterling G, Kliem M, Schroeder FC, Sauer S. Weidner C, et al. Among authors: kliem m. J Nat Prod. 2016 Jan 22;79(1):2-12. doi: 10.1021/acs.jnatprod.5b00072. Epub 2016 Jan 5. J Nat Prod. 2016. PMID: 26731300
Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties.
Weidner C, Wowro SJ, Freiwald A, Kawamoto K, Witzke A, Kliem M, Siems K, Müller-Kuhrt L, Schroeder FC, Sauer S. Weidner C, et al. Among authors: kliem m. Diabetologia. 2013 Aug;56(8):1802-12. doi: 10.1007/s00125-013-2920-2. Epub 2013 May 18. Diabetologia. 2013. PMID: 23680913
Amorfrutins are potent antidiabetic dietary natural products.
Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K, Sauer S. Weidner C, et al. Among authors: kliem m. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7257-62. doi: 10.1073/pnas.1116971109. Epub 2012 Apr 16. Proc Natl Acad Sci U S A. 2012. PMID: 22509006 Free PMC article.
The essence on mass spectrometry based microbial diagnostics.
Kliem M, Sauer S. Kliem M, et al. Curr Opin Microbiol. 2012 Jun;15(3):397-402. doi: 10.1016/j.mib.2012.02.006. Epub 2012 Mar 10. Curr Opin Microbiol. 2012. PMID: 22410108 Review.
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