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Page 1
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.
Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q. Tripathi P, et al. Among authors: klim jr. Stem Cell Reports. 2017 Aug 8;9(2):667-680. doi: 10.1016/j.stemcr.2017.06.008. Epub 2017 Jul 14. Stem Cell Reports. 2017. PMID: 28712846 Free PMC article.
How to make spinal motor neurons.
Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K. Davis-Dusenbery BN, et al. Among authors: klim jr. Development. 2014 Feb;141(3):491-501. doi: 10.1242/dev.097410. Development. 2014. PMID: 24449832 Review.
Modeling ALS with motor neurons derived from human induced pluripotent stem cells.
Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Sances S, et al. Among authors: klim jr. Nat Neurosci. 2016 Apr;19(4):542-53. doi: 10.1038/nn.4273. Nat Neurosci. 2016. PMID: 27021939 Free PMC article. Review.
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.
Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. Mordes DA, et al. Among authors: klim jr. Acta Neuropathol Commun. 2018 Jul 4;6(1):55. doi: 10.1186/s40478-018-0555-8. Acta Neuropathol Commun. 2018. PMID: 29973287 Free PMC article.
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.
Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S; ALSGENS Consortium; FALS Consortium; Project MinE Consortium; CReATe Consortium; Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. Farhan SMK, et al. Among authors: klim jr. Nat Neurosci. 2019 Dec;22(12):1966-1974. doi: 10.1038/s41593-019-0530-0. Epub 2019 Nov 25. Nat Neurosci. 2019. PMID: 31768050 Free PMC article.
Connecting TDP-43 Pathology with Neuropathy.
Klim JR, Pintacuda G, Nash LA, Guerra San Juan I, Eggan K. Klim JR, et al. Trends Neurosci. 2021 Jun;44(6):424-440. doi: 10.1016/j.tins.2021.02.008. Epub 2021 Apr 5. Trends Neurosci. 2021. PMID: 33832769 Review.
Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation.
Huang X, Roet KCD, Zhang L, Brault A, Berg AP, Jefferson AB, Klug-McLeod J, Leach KL, Vincent F, Yang H, Coyle AJ, Jones LH, Frost D, Wiskow O, Chen K, Maeda R, Grantham A, Dornon MK, Klim JR, Siekmann MT, Zhao D, Lee S, Eggan K, Woolf CJ. Huang X, et al. Among authors: klim jr. Cell Rep. 2021 Jun 8;35(10):109224. doi: 10.1016/j.celrep.2021.109224. Cell Rep. 2021. PMID: 34107252 Free PMC article.
Loss of mouse Stmn2 function causes motor neuropathy.
Guerra San Juan I, Nash LA, Smith KS, Leyton-Jaimes MF, Qian M, Klim JR, Limone F, Dorr AB, Couto A, Pintacuda G, Joseph BJ, Whisenant DE, Noble C, Melnik V, Potter D, Holmes A, Burberry A, Verhage M, Eggan K. Guerra San Juan I, et al. Among authors: klim jr. Neuron. 2022 May 18;110(10):1671-1688.e6. doi: 10.1016/j.neuron.2022.02.011. Epub 2022 Mar 15. Neuron. 2022. PMID: 35294901 Free PMC article.
21 results