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Promoter of FGF8 reveals a unique regulation by unliganded RARalpha.
Brondani V, Klimkait T, Egly JM, Hamy F. Brondani V, et al. J Mol Biol. 2002 Jun 7;319(3):715-28. doi: 10.1016/S0022-2836(02)00376-5. J Mol Biol. 2002. PMID: 12054865
A neutravidin-based assay for reverse transcriptase suitable for high throughput screening of retroviral activity.
Brennan LE, Suñé C, Klimkait T. Brennan LE, et al. J Biochem Mol Biol. 2002 May 31;35(3):262-6. doi: 10.5483/bmbrep.2002.35.3.262. J Biochem Mol Biol. 2002. PMID: 12297021
Using a 96-well microtitre plate, HIV particles are lysed and the RT enzyme released into a reaction mixture containing poly(A) RNA, biotinylated oligo d(T) and fluorescein-labelled dUTP (FI-dUTP). With poly(A) as a template and oligo d(T) as primer, the viron RT in …
Using a 96-well microtitre plate, HIV particles are lysed and the RT enzyme released into a reaction mixture containing poly(A) RNA, biotiny …
The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor alpha stability.
Brondani V, Schefer Q, Hamy F, Klimkait T. Brondani V, et al. Biochem Biophys Res Commun. 2005 Mar 4;328(1):6-13. doi: 10.1016/j.bbrc.2004.12.130. Biochem Biophys Res Commun. 2005. PMID: 15670742
Pin1 is a PPIase, which specifically recognizes phosphorylated S/T-P bonds. The transcription factor TFIIH mediates phosphorylation of the retinoic acid receptor alpha (RARalpha) at position Ser77. ...
Pin1 is a PPIase, which specifically recognizes phosphorylated S/T-P bonds. The transcription factor TFIIH mediates phosphorylation o …
Estimating the basic reproductive number from viral sequence data.
Stadler T, Kouyos R, von Wyl V, Yerly S, Böni J, Bürgisser P, Klimkait T, Joos B, Rieder P, Xie D, Günthard HF, Drummond AJ, Bonhoeffer S; Swiss HIV Cohort Study. Stadler T, et al. Mol Biol Evol. 2012 Jan;29(1):347-57. doi: 10.1093/molbev/msr217. Epub 2011 Sep 2. Mol Biol Evol. 2012. PMID: 21890480
Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains.
Weber J, Mesters JR, Lepsík M, Prejdová J, Svec M, Sponarová J, Mlcochová P, Skalická K, Strísovský K, Uhlíková T, Soucek M, Machala L, Stanková M, Vondrásek J, Klimkait T, Kraeusslich HG, Hilgenfeld R, Konvalinka J. Weber J, et al. J Mol Biol. 2002 Dec 6;324(4):739-54. doi: 10.1016/s0022-2836(02)01139-7. J Mol Biol. 2002. PMID: 12460574
A diagnostic HIV-1 tropism system based on sequence relatedness.
Edwards S, Stucki H, Bader J, Vidal V, Kaiser R, Battegay M, Klimkait T; Swiss HIV Cohort Study. Edwards S, et al. J Clin Microbiol. 2015 Feb;53(2):597-610. doi: 10.1128/JCM.02762-14. Epub 2014 Dec 10. J Clin Microbiol. 2015. PMID: 25502529 Free PMC article.
Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.
Bertels F, Marzel A, Leventhal G, Mitov V, Fellay J, Günthard HF, Böni J, Yerly S, Klimkait T, Aubert V, Battegay M, Rauch A, Cavassini M, Calmy A, Bernasconi E, Schmid P, Scherrer AU, Müller V, Bonhoeffer S, Kouyos R, Regoes RR; Swiss HIV Cohort Study. Bertels F, et al. Mol Biol Evol. 2018 Jan 1;35(1):27-37. doi: 10.1093/molbev/msx246. Mol Biol Evol. 2018. PMID: 29029206 Free PMC article.
Using viral load and CD4+ T-cell measures from 2014 HIV-1 subtype B-infected individuals enrolled in the Swiss HIV Cohort Study, we investigated if virulence-measured as the rate of decline of CD4+ T cells-and per-parasite pathogenicity are heritable from donor to r …
Using viral load and CD4+ T-cell measures from 2014 HIV-1 subtype B-infected individuals enrolled in the Swiss HIV Cohort Study, we i …
A sensitive replicative system to assess HIV-1 drug resistance.
Klimkait T. Klimkait T. Am Clin Lab. 2002 Jan-Feb;21(1):20-4. Am Clin Lab. 2002. PMID: 11975445 Review. No abstract available.
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