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Surveillance for influenza--United States, 1997-98, 1998-99, and 1999-00 seasons.
Brammer TL, Murray EL, Fukuda K, Hall HE, Klimov A, Cox NJ. Brammer TL, et al. Among authors: klimov a. MMWR Surveill Summ. 2002 Oct 25;51(7):1-10. MMWR Surveill Summ. 2002. PMID: 12418623
During the 1999-00 season, influenza A(H3N2) viruses predominated, but influenza A(H1N1) and B viruses also were identified. ...INTERPRETATION: Influenza A(H1N1), A(H3N2), and B viruses circulated during 1997-2000, but influenza A(H3N2) was the …
During the 1999-00 season, influenza A(H3N2) viruses predominated, but influenza A(H1N1) and B viruses also were identified. . …
Selection of antigenically advanced variants of seasonal influenza viruses.
Li C, Hatta M, Burke DF, Ping J, Zhang Y, Ozawa M, Taft AS, Das SC, Hanson AP, Song J, Imai M, Wilker PR, Watanabe T, Watanabe S, Ito M, Iwatsuki-Horimoto K, Russell CA, James SL, Skepner E, Maher EA, Neumann G, Klimov AI, Kelso A, McCauley J, Wang D, Shu Y, Odagiri T, Tashiro M, Xu X, Wentworth DE, Katz JM, Cox NJ, Smith DJ, Kawaoka Y. Li C, et al. Among authors: klimov ai. Nat Microbiol. 2016 May 23;1(6):16058. doi: 10.1038/nmicrobiol.2016.58. Nat Microbiol. 2016. PMID: 27572841 Free PMC article.
Rapid strategy for screening by pyrosequencing of influenza virus reassortants--candidates for live attenuated vaccines.
Shcherbik SV, Pearce NC, Levine ML, Klimov AI, Villanueva JM, Bousse TL. Shcherbik SV, et al. Among authors: klimov ai. PLoS One. 2014 Mar 19;9(3):e92580. doi: 10.1371/journal.pone.0092580. eCollection 2014. PLoS One. 2014. PMID: 24647786 Free PMC article.
BACKGROUND: Live attenuated influenza vaccine viruses (LAIVs) can be generated by classical reassortment of gene segments between a cold adapted, temperature sensitive and attenuated Master Donor Virus (MDV) and a seasonal wild-type (wt) virus. ...LAIV candidate vir …
BACKGROUND: Live attenuated influenza vaccine viruses (LAIVs) can be generated by classical reassortment of gene segments between a c …
WHO recommendations for the viruses to be used in the 2012 Southern Hemisphere Influenza Vaccine: epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from February to September 2011.
Klimov AI, Garten R, Russell C, Barr IG, Besselaar TG, Daniels R, Engelhardt OG, Grohmann G, Itamura S, Kelso A, McCauley J, Odagiri T, Smith D, Tashiro M, Xu X, Webby R, Wang D, Ye Z, Yuelong S, Zhang W, Cox N; Writing Committee of the World Health Organization Consultation on Southern Hemisphere Influenza Vaccine Composition for 2012. Klimov AI, et al. Vaccine. 2012 Oct 5;30(45):6461-71. doi: 10.1016/j.vaccine.2012.07.089. Epub 2012 Aug 20. Vaccine. 2012. PMID: 22917957 Free PMC article.
These recommendations are based on data collected by National Influenza Centres (NIC) through the Global Influenza Surveillance and Response System (GISRS) and a more detailed analysis of representative and potential antigenically variant influenza viruses from the WHO Col …
These recommendations are based on data collected by National Influenza Centres (NIC) through the Global Influenza Surveillance and Response …
Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses.
Sandbulte MR, Westgeest KB, Gao J, Xu X, Klimov AI, Russell CA, Burke DF, Smith DJ, Fouchier RA, Eichelberger MC. Sandbulte MR, et al. Among authors: klimov ai. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20748-53. doi: 10.1073/pnas.1113801108. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143798 Free PMC article.
Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evolution of each protein in H1N1 and H3N2 viruses used in vaccine formulations during the last 15 y by analysis of HA and NA inhibition titers …
Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evol …
Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses.
Russell CA, Jones TC, Barr IG, Cox NJ, Garten RJ, Gregory V, Gust ID, Hampson AW, Hay AJ, Hurt AC, de Jong JC, Kelso A, Klimov AI, Kageyama T, Komadina N, Lapedes AS, Lin YP, Mosterin A, Obuchi M, Odagiri T, Osterhaus AD, Rimmelzwaan GF, Shaw MW, Skepner E, Stohr K, Tashiro M, Fouchier RA, Smith DJ. Russell CA, et al. Among authors: klimov ai. Vaccine. 2008 Sep 12;26 Suppl 4:D31-4. doi: 10.1016/j.vaccine.2008.07.078. Vaccine. 2008. PMID: 19230156 Review.
For example, since the influenza A(H3N2) subtype entered the human population in 1968 the A(H3N2) component of the influenza vaccine has had to be updated almost 30 times to track the evolution of the viruses and remain effective. ...
For example, since the influenza A(H3N2) subtype entered the human population in 1968 the A(H3N2) component of the influenza v …
The global circulation of seasonal influenza A (H3N2) viruses.
Russell CA, Jones TC, Barr IG, Cox NJ, Garten RJ, Gregory V, Gust ID, Hampson AW, Hay AJ, Hurt AC, de Jong JC, Kelso A, Klimov AI, Kageyama T, Komadina N, Lapedes AS, Lin YP, Mosterin A, Obuchi M, Odagiri T, Osterhaus AD, Rimmelzwaan GF, Shaw MW, Skepner E, Stohr K, Tashiro M, Fouchier RA, Smith DJ. Russell CA, et al. Among authors: klimov ai. Science. 2008 Apr 18;320(5874):340-6. doi: 10.1126/science.1154137. Science. 2008. PMID: 18420927
Antigenic and genetic analysis of the hemagglutinin of approximately 13,000 human influenza A (H3N2) viruses from six continents during 2002-2007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of tempo …
Antigenic and genetic analysis of the hemagglutinin of approximately 13,000 human influenza A (H3N2) viruses from six continents duri …
Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008.
Sheu TG, Deyde VM, Okomo-Adhiambo M, Garten RJ, Xu X, Bright RA, Butler EN, Wallis TR, Klimov AI, Gubareva LV. Sheu TG, et al. Among authors: klimov ai. Antimicrob Agents Chemother. 2008 Sep;52(9):3284-92. doi: 10.1128/AAC.00555-08. Epub 2008 Jul 14. Antimicrob Agents Chemother. 2008. PMID: 18625765 Free PMC article.
Based on mean IC(50)s, A(H3N2) viruses (0.44 nM) were more sensitive to oseltamivir than A(H1N1) viruses (0.91 nM). The opposite trend was observed with zanamivir: 1.06 nM for A(H1N1) and 2.54 nM for A(H3N2). ...Molecular markers of oseltamivir resista …
Based on mean IC(50)s, A(H3N2) viruses (0.44 nM) were more sensitive to oseltamivir than A(H1N1) viruses (0.91 nM). The opposi …
Seasonality, timing, and climate drivers of influenza activity worldwide.
Azziz Baumgartner E, Dao CN, Nasreen S, Bhuiyan MU, Mah-E-Muneer S, Al Mamun A, Sharker MA, Zaman RU, Cheng PY, Klimov AI, Widdowson MA, Uyeki TM, Luby SP, Mounts A, Bresee J. Azziz Baumgartner E, et al. Among authors: klimov ai. J Infect Dis. 2012 Sep 15;206(6):838-46. doi: 10.1093/infdis/jis467. Epub 2012 Jul 24. J Infect Dis. 2012. PMID: 22829641
BACKGROUND: Although influenza is a vaccine-preventable disease that annually causes substantial disease burden, data on virus activity in tropical countries are limited. ...
BACKGROUND: Although influenza is a vaccine-preventable disease that annually causes substantial disease burden, data on virus activi …
Diagnosis of influenza from respiratory autopsy tissues: detection of virus by real-time reverse transcription-PCR in 222 cases.
Denison AM, Blau DM, Jost HA, Jones T, Rollin D, Gao R, Liu L, Bhatnagar J, Deleon-Carnes M, Shieh WJ, Paddock CD, Drew C, Adem P, Emery SL, Shu B, Wu KH, Batten B, Greer PW, Smith CS, Bartlett J, Montague JL, Patel M, Xu X, Lindstrom S, Klimov AI, Zaki SR. Denison AM, et al. Among authors: klimov ai. J Mol Diagn. 2011 Mar;13(2):123-8. doi: 10.1016/j.jmoldx.2010.09.004. J Mol Diagn. 2011. PMID: 21354045 Free PMC article.
The recent influenza pandemic, caused by a novel H1N1 influenza A virus, as well as the seasonal influenza outbreaks caused by varieties of influenza A and B viruses, are responsible for hundreds of thousands of deaths worldwide. ...In this work, respiratory …
The recent influenza pandemic, caused by a novel H1N1 influenza A virus, as well as the seasonal influenza outbreaks caused by …
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