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The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function.
Chai L, McLaren RP, Byrne A, Chuang WL, Huang Y, Dufault MR, Pacheco J, Madhiwalla S, Zhang X, Zhang M, Teicher BA, Carter K, Cheng SH, Leonard JP, Xiang Y, Vasconcelles M, Goldberg MA, Copeland DP, Klinger KW, Lillie J, Madden SL, Jiang YA. Chai L, et al. Among authors: klinger kw. Int J Oncol. 2011 Mar;38(3):701-11. doi: 10.3892/ijo.2010.888. Epub 2010 Dec 24. Int J Oncol. 2011. PMID: 21186402
Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence.
Byrne A, McLaren RP, Mason P, Chai L, Dufault MR, Huang Y, Liang B, Gans JD, Zhang M, Carter K, Gladysheva TB, Teicher BA, Biemann HP, Booker M, Goldberg MA, Klinger KW, Lillie J, Madden SL, Jiang Y. Byrne A, et al. Among authors: klinger kw. Exp Cell Res. 2010 Jan 15;316(2):258-71. doi: 10.1016/j.yexcr.2009.08.018. Epub 2009 Sep 2. Exp Cell Res. 2010. PMID: 19732767
Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.
Natoli TA, Husson H, Rogers KA, Smith LA, Wang B, Budman Y, Bukanov NO, Ledbetter SR, Klinger KW, Leonard JP, Ibraghimov-Beskrovnaya O. Natoli TA, et al. Among authors: klinger kw. Hum Mol Genet. 2012 Aug 1;21(15):3397-407. doi: 10.1093/hmg/dds172. Epub 2012 May 4. Hum Mol Genet. 2012. PMID: 22563011 Free PMC article.
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
Morgenbesser SD, McLaren RP, Richards B, Zhang M, Akmaev VR, Winter SF, Mineva ND, Kaplan-Lefko PJ, Foster BA, Cook BP, Dufault MR, Cao X, Wang CJ, Teicher BA, Klinger KW, Greenberg NM, Madden SL. Morgenbesser SD, et al. Among authors: klinger kw. Prostate. 2007 Jan 1;67(1):83-106. doi: 10.1002/pros.20505. Prostate. 2007. PMID: 17013881
102 results