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Page 1
Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion.
Weger M, Mauvoisin D, Hoyle D, Wang J, Martin E, Rae J, Ferguson C, Klinke G, Cielesh M, Macauslane KL, Larance M, Quadroni M, Templeman I, Walhin JP, Karagounis LG, Betts JA, Johnston JD, Durussel F, Firsov D, Fournier S, Müller O, Schulz BL, Parton RG, Weger BD, Gachon F. Weger M, et al. Among authors: klinke g. Nat Metab. 2026 Feb;8(2):327-349. doi: 10.1038/s42255-026-01453-8. Epub 2026 Feb 5. Nat Metab. 2026. PMID: 41644694 Free PMC article.
The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate.
Weisshaar N, Ma S, Ming Y, Madi A, Mieg A, Hering M, Zettl F, Mohr K, Ten Bosch N, Stichling D, Buettner M, Poschet G, Klinke G, Schulz M, Kunze-Rohrbach N, Kerber C, Klein IM, Wu J, Wang X, Cui G. Weisshaar N, et al. Among authors: klinke g. Nat Immunol. 2023 Nov;24(11):1921-1932. doi: 10.1038/s41590-023-01636-5. Epub 2023 Oct 9. Nat Immunol. 2023. PMID: 37813964 Free PMC article.
mTORC1 senses glutamine and other amino acids through GCN2.
Figlia G, Müller S, Garcia-Cortizo F, Neff M, Klinke G, Poschet G, Teleman AA. Figlia G, et al. Among authors: klinke g. EMBO J. 2025 Sep;44(17):4825-4866. doi: 10.1038/s44318-025-00505-1. Epub 2025 Jul 21. EMBO J. 2025. PMID: 40691417 Free PMC article.
Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.
Kumari M, Evangelakos I, Deshpande A, De Jong KA, Schmiedel N, Palacio-Escat N, Chaves-Filho AB, Frias-Soler RC, Klinke G, Roh HC, Lange L, Berlin M, Fuh MM, Buss JJ, Tian T, Lerchenmüller C, Freichel M, Schulze A, Nikolaev VO, Eschenhagen T, Rosen ED, Scheja L, Rangrez AY, Heeren J, Frey N. Kumari M, et al. Among authors: klinke g. Nat Commun. 2026 Feb 27;17(1):2051. doi: 10.1038/s41467-026-69792-4. Nat Commun. 2026. PMID: 41760613 Free PMC article.
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
Steimbach RR, Herbst-Gervasoni CJ, Lechner S, Stewart TM, Klinke G, Ridinger J, Géraldy MNE, Tihanyi G, Foley JR, Uhrig U, Kuster B, Poschet G, Casero RA Jr, Médard G, Oehme I, Christianson DW, Gunkel N, Miller AK. Steimbach RR, et al. Among authors: klinke g. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875. doi: 10.1021/jacs.2c05030. Epub 2022 Oct 6. J Am Chem Soc. 2022. PMID: 36200994 Free PMC article.
28 results