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Glucose uptake in human and animal muscle cells in culture.
Sarabia V, Ramlal T, Klip A. Sarabia V, et al. Biochem Cell Biol. 1990 Feb;68(2):536-42. doi: 10.1139/o90-076. Biochem Cell Biol. 1990. PMID: 2188683
However, insulin (10(-6) M) stimulated hexose uptake to a larger extent (2.37-fold) in L6 than in either human (1.58-fold) or mouse (1.39-fold) myotubes. ...
However, insulin (10(-6) M) stimulated hexose uptake to a larger extent (2.37-fold) in L6 than in either human (1.58-fold) or mouse ( …
Development regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells.
Mitsumoto Y, Klip A. Mitsumoto Y, et al. J Biol Chem. 1992 Mar 5;267(7):4957-62. J Biol Chem. 1992. PMID: 1311324
In myotubes, acute insulin treatment increased the crude plasma membrane content of GLUT1 marginally and of GLUT4 markedly, with a concomitant decrease in the light microsomal fraction. These results indicate that: (a) the subcellular distribution of glucose transpo …
In myotubes, acute insulin treatment increased the crude plasma membrane content of GLUT1 marginally and of GLUT4 markedly, with a co …
Acute and long-term effects of insulin-like growth factor I on glucose transporters in muscle cells. Translocation and biosynthesis.
Bilan PJ, Mitsumoto Y, Ramlal T, Klip A. Bilan PJ, et al. FEBS Lett. 1992 Feb 24;298(2-3):285-90. doi: 10.1016/0014-5793(92)80078-u. FEBS Lett. 1992. PMID: 1312027
Uptake remained stimulated at a steady level for 1-2 h, after which a second stimulation occurred. The first phase was insensitive to inhibition of protein synthesis. ...The second phase of stimulation was inhibitable by cycloheximide, and involved a net incr …
Uptake remained stimulated at a steady level for 1-2 h, after which a second stimulation occurred. The first phase was insensi …
Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.
Hundal HS, Marette A, Mitsumoto Y, Ramlal T, Blostein R, Klip A. Hundal HS, et al. J Biol Chem. 1992 Mar 15;267(8):5040-3. J Biol Chem. 1992. PMID: 1312081
After insulin treatment, alpha 2 content in the PM increased, with a parallel decrease in its abundance in the IM pool; insulin did not have any effect on alpha 1 isoform amount or subcellular distribution. The beta 1 subunit, but not beta 2, was also elevated in the PM af …
After insulin treatment, alpha 2 content in the PM increased, with a parallel decrease in its abundance in the IM pool; insulin did n …
Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture.
Bashan N, Burdett E, Hundal HS, Klip A. Bashan N, et al. Am J Physiol. 1992 Mar;262(3 Pt 1):C682-90. doi: 10.1152/ajpcell.1992.262.3.C682. Am J Physiol. 1992. PMID: 1312781
Incubation of L6 myotubes in 3% O2 (mimicking a state of hypoxia) elevated glucose uptake by 6.5-fold over 48 h relative to cells incubated in 21% O2 (normoxia). ...
Incubation of L6 myotubes in 3% O2 (mimicking a state of hypoxia) elevated glucose uptake by 6.5-fold over 48 h relative to cells inc …
Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin.
Sarabia V, Lam L, Burdett E, Leiter LA, Klip A. Sarabia V, et al. J Clin Invest. 1992 Oct;90(4):1386-95. doi: 10.1172/JCI116005. J Clin Invest. 1992. PMID: 1401073 Free PMC article.
Cytochalasin B photolabeled a protein(s) of 45,000-50,000 D in a D-glucose-protectable manner, suggesting identity with the glucose transporters. ...Insulin elevated 2-deoxyglucose uptake in a dose-dependent manner, with half maximal stimulation achieved at 3 …
Cytochalasin B photolabeled a protein(s) of 45,000-50,000 D in a D-glucose-protectable manner, suggesting identity with the gl …
Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle.
Marette A, Burdett E, Douen A, Vranic M, Klip A. Marette A, et al. Diabetes. 1992 Dec;41(12):1562-9. doi: 10.2337/diab.41.12.1562. Diabetes. 1992. PMID: 1446797
We have shown previously that insulin induces a rapid translocation of GLUT4s from an IM pool to the PM in rat skeletal muscle (6). ...In contrast, estimation of the content of Ca(2+)-ATPase protein (a marker of SR) with a specific polyclonal antibody reveale …
We have shown previously that insulin induces a rapid translocation of GLUT4s from an IM pool to the PM in rat skeletal muscle (6). . …
Effect of diabetes on glucoregulation. From glucose transporters to glucose metabolism in vivo.
Klip A, Marette A, Dimitrakoudis D, Ramlal T, Giacca A, Shi ZQ, Vranic M. Klip A, et al. Diabetes Care. 1992 Nov;15(11):1747-66. doi: 10.2337/diacare.15.11.1747. Diabetes Care. 1992. PMID: 1468312 Review.
In skeletal muscles of streptozocin-induced diabetic rats, there is a decreased GLUT4 protein content in intracellular and plasma membranes. ...Finally, we postulated a neural pathway that requires the permissive effect of insulin to increase glucose uptake by the m …
In skeletal muscles of streptozocin-induced diabetic rats, there is a decreased GLUT4 protein content in intracellular and plasma mem …
Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia.
Dimitrakoudis D, Vranic M, Klip A. Dimitrakoudis D, et al. J Am Soc Nephrol. 1992 Nov;3(5):1078-91. J Am Soc Nephrol. 1992. PMID: 1482748 Review.
Therefore, it is possible that a defect exists in insulin-dependent glucose transport in skeletal muscle in diabetic states. This review focuses on two questions: is there a defect at the level of glucose transporters in skeletal muscle of diabetic animal models, an …
Therefore, it is possible that a defect exists in insulin-dependent glucose transport in skeletal muscle in diabetic states. This rev …
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