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Oxytocin and potential benefits for obesity treatment.
Olszewski PK, Klockars A, Levine AS. Olszewski PK, et al. Among authors: klockars a. Curr Opin Endocrinol Diabetes Obes. 2017 Oct;24(5):320-325. doi: 10.1097/MED.0000000000000351. Curr Opin Endocrinol Diabetes Obes. 2017. PMID: 28590323 Review.
PURPOSE OF REVIEW: Laboratory animal experiments have consistently shown that oxytocin causes early termination of food intake, thereby promoting a decrease in body weight in a long term. ...RECENT FINDINGS: Basic research indicates the involvement of oxytocin in sa …
PURPOSE OF REVIEW: Laboratory animal experiments have consistently shown that oxytocin causes early termination of food intake, thereby prom …
Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin.
Mitra A, Gosnell BA, Schiöth HB, Grace MK, Klockars A, Olszewski PK, Levine AS. Mitra A, et al. Among authors: klockars a. Peptides. 2010 Jul;31(7):1346-52. doi: 10.1016/j.peptides.2010.04.005. Epub 2010 Apr 22. Peptides. 2010. PMID: 20399242 Free PMC article.
Interestingly, some of these reward orexigens, such as opioids, diminish activity of neurons synthesizing oxytocin, a nonapeptide that promotes satiety and feeding termination. ...We speculate that a reduction in central satiety signaling precipitated by regular int …
Interestingly, some of these reward orexigens, such as opioids, diminish activity of neurons synthesizing oxytocin, a nonapeptide tha …
Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness.
Olszewski PK, Grace MK, Fard SS, Le Grevès M, Klockars A, Massi M, Schiöth HB, Levine AS. Olszewski PK, et al. Among authors: klockars a. Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R655-63. doi: 10.1152/ajpregu.00556.2009. Epub 2010 Apr 28. Am J Physiol Regul Integr Comp Physiol. 2010. PMID: 20427724 Free PMC article.
Prepro-N/OFQ mRNA showed a trend toward upregulation in restricted rats (P = 0.068). We conclude that the N/OFQ system promotes feeding by affecting the need to replenish lacking calories and by reducing aversive responsiveness. It may belong to mechanisms that shift a
Prepro-N/OFQ mRNA showed a trend toward upregulation in restricted rats (P = 0.068). We conclude that the N/OFQ system promotes feedi …
Oxytocin as feeding inhibitor: maintaining homeostasis in consummatory behavior.
Olszewski PK, Klockars A, Schiöth HB, Levine AS. Olszewski PK, et al. Among authors: klockars a. Pharmacol Biochem Behav. 2010 Nov;97(1):47-54. doi: 10.1016/j.pbb.2010.05.026. Epub 2010 Jun 2. Pharmacol Biochem Behav. 2010. PMID: 20595062 Free PMC article. Review.
Most recently, it has been proposed to act as a mediator of general and carbohydrate-specific satiety and regulator of body weight. In the current review, we discuss the function of OT as a homeostatic inhibitor of consumption, capable of mitigating multiple aspects …
Most recently, it has been proposed to act as a mediator of general and carbohydrate-specific satiety and regulator of body weight. I …
Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake.
Olszewski PK, Klockars A, Olszewska AM, Fredriksson R, Schiöth HB, Levine AS. Olszewski PK, et al. Among authors: klockars a. Endocrinology. 2010 Oct;151(10):4736-44. doi: 10.1210/en.2010-0151. Epub 2010 Aug 4. Endocrinology. 2010. PMID: 20685878 Free PMC article.
Therefore, we examined the involvement of OT in the regulation of sucrose vs. fat intake in C57BL/6 mice that served as a background KO strain. ...The current findings expand our knowledge on OT and suggest that it acts as a carbohydrate-specific inhibitor of feedin …
Therefore, we examined the involvement of OT in the regulation of sucrose vs. fat intake in C57BL/6 mice that served as a background …
Central oxytocin and food intake: focus on macronutrient-driven reward.
Klockars A, Levine AS, Olszewski PK. Klockars A, et al. Front Endocrinol (Lausanne). 2015 Apr 28;6:65. doi: 10.3389/fendo.2015.00065. eCollection 2015. Front Endocrinol (Lausanne). 2015. PMID: 25972841 Free PMC article. Review.
In this mini-review, we focus on presenting and interpreting evidence that defines OT as a key component of mechanisms that reduce eating for pleasure and shape macronutrient preferences. ...
In this mini-review, we focus on presenting and interpreting evidence that defines OT as a key component of mechanisms that reduce ea …
Oxytocin: A Conditional Anorexigen whose Effects on Appetite Depend on the Physiological, Behavioural and Social Contexts.
Olszewski PK, Klockars A, Levine AS. Olszewski PK, et al. Among authors: klockars a. J Neuroendocrinol. 2016 Apr;28(4). doi: 10.1111/jne.12376. J Neuroendocrinol. 2016. PMID: 26918919 Review.
This review summarises current knowledge of the role of oxytocin in food intake regulation and highlights a growing body of evidence showing that oxytocin is a conditional anorexigen [i.e. its effects on appetite differ significantly with respect to certain (patho)p …
This review summarises current knowledge of the role of oxytocin in food intake regulation and highlights a growing body of evidence …
Central oxytocin receptor stimulation attenuates the orexigenic effects of butorphanol tartrate.
Olszewski PK, Klockars OA, Klockars A, Levine AS. Olszewski PK, et al. Among authors: klockars oa, klockars a. Neuroreport. 2016 Sep 28;27(14):1012-7. doi: 10.1097/WNR.0000000000000647. Neuroreport. 2016. PMID: 27471903
BT-induced chow intake in hungry and sated animals was suppressed by a very low, 0.1 μg dose of 4V OT, whereas 1 μg OT was effective LV. ...Reduced activity of the OT circuit, especially its hindbrain component, is a critical factor in shaping the magnitude of consu …
BT-induced chow intake in hungry and sated animals was suppressed by a very low, 0.1 μg dose of 4V OT, whereas 1 μg OT was effective …
Intravenous administration of oxytocin in rats acutely decreases deprivation-induced chow intake, but it fails to affect consumption of palatable solutions.
Klockars A, Brunton C, Li L, Levine AS, Olszewski PK. Klockars A, et al. Peptides. 2017 Jul;93:13-19. doi: 10.1016/j.peptides.2017.04.010. Epub 2017 Apr 28. Peptides. 2017. PMID: 28460894
Intralipid and it failed to affect daily scheduled consumption of a sucrose solution in non-deprived rats. In a two-bottle choice test, IV OT did not shift animals' preference from sucrose to Intralipid. Finally, OT injected IV prior to the simultaneous presentation …
Intralipid and it failed to affect daily scheduled consumption of a sucrose solution in non-deprived rats. In a two-bottle cho …
Neural Basis of Ventromedial Hypothalamic Oxytocin-Driven Decrease in Appetite.
Klockars OA, Waas JR, Klockars A, Levine AS, Olszewski PK. Klockars OA, et al. Among authors: klockars a. Neuroscience. 2017 Dec 16;366:54-61. doi: 10.1016/j.neuroscience.2017.10.008. Epub 2017 Oct 14. Neuroscience. 2017. PMID: 29037599
Here we provide insight into neural mechanisms underlying VMH OT-driven anorexia by (a) identifying feeding-related brain sites activated by VMH OT injection; (b) measuring VMH OT receptor (OTr) mRNA changes in response to hunger and palatability; and (c) examining how VMH …
Here we provide insight into neural mechanisms underlying VMH OT-driven anorexia by (a) identifying feeding-related brain sites activ …
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