Protein promiscuity: drug resistance and native functions--HIV-1 case.
Fernández A, Tawfik DS, Berkhout B, Sanders R, Kloczkowski A, Sen T, Jernigan B.
Fernández A, et al. Among authors: kloczkowski a.
J Biomol Struct Dyn. 2005 Jun;22(6):615-24. doi: 10.1080/07391102.2005.10531228.
J Biomol Struct Dyn. 2005.
PMID: 15842167
The association of a drug with its target protein has the effect of blocking the protein activity and is termed a promiscuous function to distinguish from the protein's native function (Tawfik and associates, Nat. ...Disordered proteins represent a more extre …
The association of a drug with its target protein has the effect of blocking the protein activity and is termed a promiscuous …