Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1997 3
1998 9
1999 3
2000 22
2001 10
2002 23
2003 12
2004 24
2005 29
2006 44
2007 62
2008 68
2009 100
2010 110
2011 131
2012 166
2013 199
2014 207
2015 237
2016 309
2017 269
2018 328
2019 340
2020 358
2021 369
2022 372
2023 356
2024 389
2025 445
2026 194

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

4,586 results

Results by year

Filters applied: . Clear all
Page 1
Cognitive impairment in chronic kidney disease: pathophysiological mechanisms and potential modulatory effects of resveratrol.
Aguilera P, Alquisiras-Burgos I, Franco-Pérez J. Aguilera P, et al. J Ren Nutr. 2026 Jun 6:S1051-2276(26)00105-6. doi: 10.1053/j.jrn.2026.05.006. Online ahead of print. J Ren Nutr. 2026. PMID: 42251988 Review.
Additional contributors include glymphatic dysfunction, mitochondrial impairment, and Klotho deficiency. Preclinical evidence indicates that resveratrol mitigates oxidative stress and neuroinflammation, enhances mitochondrial function via SIRT1/PGC-1alpha signaling, improv …
Additional contributors include glymphatic dysfunction, mitochondrial impairment, and Klotho deficiency. Preclinical evidence indicat …
Body composition, muscle strength and novel biomarkers in acute heart failure patients: a comprehensive frailty assessment.
Iturriaga T, Margalejo A, Sal-de-Rellán A, Aguilar-Iglesias L, Baos S, Saez-Maleta R, Capo X, Gonzalez-Freire M, Santiago C, Perez-Rivera JA. Iturriaga T, et al. Nutr Metab Cardiovasc Dis. 2026 May 14:104804. doi: 10.1016/j.numecd.2026.104804. Online ahead of print. Nutr Metab Cardiovasc Dis. 2026. PMID: 42236380
Frail HF patients showed lower bone mineral density (p = 0.016) and reduced handgrip strength (p = 0.002) compared with non-frail HF patients. Trends toward lower Klotho and higher GDF-15 were also observed. Relative to controls, HF patients exhibited higher GDF-15 (p < …
Frail HF patients showed lower bone mineral density (p = 0.016) and reduced handgrip strength (p = 0.002) compared with non-frail HF patient …
Allopurinol has no effect on calcitriol or other CKD-MBD biomarkers: a randomized double-blind study.
Costa TE, Lauar JC, Innecchi MLR, Araujo LKRP, Coelho VA, Dos Reis LM, Moysés RMA, Elias RM. Costa TE, et al. J Endocr Soc. 2026 May 21;10(6):bvag118. doi: 10.1210/jendso/bvag118. eCollection 2026 Jun. J Endocr Soc. 2026. PMID: 42232530 Free PMC article.
Clinical data and blood samples were collected at baseline and at the end of the follow-up period to assess changes in calcium, phosphate, 25-hydroxyvitamin-D, parathyroid hormone (PTH), 1,25-hydroxyvitamin D, fibroblast growth factor 23 (FGF23), alpha Klotho, and bone alk …
Clinical data and blood samples were collected at baseline and at the end of the follow-up period to assess changes in calcium, phosphate, 2 …
[Progress in prognostic assessment methods for mild cognitive impairment].
Lin J, Yu G. Lin J, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2026 May 31:1-16. doi: 10.3724/zdxbyxb-2025-0669. Online ahead of print. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2026. PMID: 42226490 Chinese.
Plasma biomarkers such as P-tau217, neurofilament light chain, glial fibrillary acidic protein (GFAP), and the Abeta42/Abeta40 ratio are suitable for screening and follow-up; combining CSF and plasma biomarkers enhances predictive performance. In contrast, Serum markers like K …
Plasma biomarkers such as P-tau217, neurofilament light chain, glial fibrillary acidic protein (GFAP), and the Abeta42/Abeta40 ratio are sui …
Role of soluble alpha-klotho as a novel biomarker for characterizing children with autism spectrum disorder in Kurdistan, Iraq.
Allwsh TA, Kucher DS. Allwsh TA, et al. World J Clin Pediatr. 2026 Jun 9;15(2):112164. doi: 10.5409/wjcp.v15.i2.112164. eCollection 2026 Jun 9. World J Clin Pediatr. 2026. PMID: 42220950 Free article.
BACKGROUND: The identification of bioindicators for the detection and monitoring of autism spectrum disorder (ASD) still remains a major challenge in clinical medicine. The protein klotho has been linked to various neurological disorders. AIM: To investigate the evaluation …
BACKGROUND: The identification of bioindicators for the detection and monitoring of autism spectrum disorder (ASD) still remains a major cha …
Conserved mRNA expression patterns of the Klotho family in canine mammary tumors and human breast cancer.
Kluppel L, Gee RRF, Plavec T, Švara T, Gutierrez JSS, Hoyos Sanchez MC, Erjavec V, Emmons J, Sheppard H, Tacer M, Štepihar D, Olivier AK, Gombač M, Rosa F, Tacer KF. Kluppel L, et al. Sci Rep. 2026 May 30. doi: 10.1038/s41598-026-54898-y. Online ahead of print. Sci Rep. 2026. PMID: 42218196 Free article.
Strikingly, we found gammaKlotho to be overexpressed in more than 65% of triple-negative breast cancer (TNBC) cases. However, the expression and role of Klothos in CMTs have not been investigated. In this study, we analyzed the mRNA expression of the Klotho family, …
Strikingly, we found gammaKlotho to be overexpressed in more than 65% of triple-negative breast cancer (TNBC) cases. However, the expression …
The association between exposure to flame retardants and cognitive function in the elderly: Unveiling potential intervention strategies.
Liu Y, Luo S, Liu J, Xu B. Liu Y, et al. Neurotoxicology. 2026 May;114:103478. doi: 10.1016/j.neuro.2026.103478. Epub 2026 May 28. Neurotoxicology. 2026. PMID: 42214759
Notably, two flame retardants, BDCPP and BCEP showed higher relative contribution weights in the WQS model, suggesting they may play a more important role in the mixture effect, pending further validation. Furthermore, Serum Klotho levels were statistically associated with …
Notably, two flame retardants, BDCPP and BCEP showed higher relative contribution weights in the WQS model, suggesting they may play a more …
Gene deletion of Klotho in the dentate gyrus does not affect the number of adult-born granule cells.
Kraus P, Marunde M, Ryzynski A, Düzel E, Kaether C, Kreutz MR, Oelschlegel AM. Kraus P, et al. Sci Rep. 2026 May 27;16(1):16415. doi: 10.1038/s41598-026-54703-w. Sci Rep. 2026. PMID: 42204218 Free PMC article.
Overexpression and exogenous administration of the anti-ageing hormone Klotho has been shown to enhance and promote adult hippocampal neurogenesis. However, whether locally produced Klotho from dentate gyrus neurons contributes to this process has remained unclear. …
Overexpression and exogenous administration of the anti-ageing hormone Klotho has been shown to enhance and promote adult hippocampal …
Universal transcriptomic hallmarks of mammalian ageing and mortality.
Tyshkovskiy A, Kholdina D, Davitadze M, Molière A, Moldakozhayev A, Tongu Y, Kasahara T, Glubokov D, Eames A, Kats LM, Vladimirova A, Ying K, Liu H, Zhang B, Khasanova U, Moqri M, Van Raamsdonk JM, Harrison DE, Strong R, Abe T, Dmitriev SE, Gladyshev VN. Tyshkovskiy A, et al. Nature. 2026 Jun;654(8117):173-188. doi: 10.1038/s41586-026-10542-3. Epub 2026 May 27. Nature. 2026. PMID: 42203874 Free PMC article.
To quantify ageing of individual cellular components, we developed module-specific clocks, which revealed pathway-specific effects of interventions: chronic diseases primarily accelerated inflammatory-module ageing, whereas caloric restriction and Klotho (also known as Kl) …
To quantify ageing of individual cellular components, we developed module-specific clocks, which revealed pathway-specific effects of interv …
VSIG4 Expression During Renal Aging Is Accelerated by Type 2 Diabetes in Mice.
Han SY, Ghee J, Cha JJ, Kim HS, Cha DR. Han SY, et al. Life (Basel). 2026 Apr 28;16(5):732. doi: 10.3390/life16050732. Life (Basel). 2026. PMID: 42195288 Free PMC article.
The intrarenal expression of VSIG4 and klotho were analyzed through immunohistochemical stating. In db/db mice, urinary albumin levels were significantly higher from 8 weeks onward compared to db/m mice. ...Intrarenal VSIG4 expression increased with age, appearing earlier …
The intrarenal expression of VSIG4 and klotho were analyzed through immunohistochemical stating. In db/db mice, urinary albumin level …
4,586 results