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Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells.
Dong LF, Kovarova J, Bajzikova M, Bezawork-Geleta A, Svec D, Endaya B, Sachaphibulkij K, Coelho AR, Sebkova N, Ruzickova A, Tan AS, Kluckova K, Judasova K, Zamecnikova K, Rychtarcikova Z, Gopalan V, Andera L, Sobol M, Yan B, Pattnaik B, Bhatraju N, Truksa J, Stopka P, Hozak P, Lam AK, Sedlacek R, Oliveira PJ, Kubista M, Agrawal A, Dvorakova-Hortova K, Rohlena J, Berridge MV, Neuzil J. Dong LF, et al. Among authors: kluckova k. Elife. 2017 Feb 15;6:e22187. doi: 10.7554/eLife.22187. Elife. 2017. PMID: 28195532 Free PMC article.
Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.
Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV. Tan AS, et al. Among authors: kluckova k. Cell Metab. 2015 Jan 6;21(1):81-94. doi: 10.1016/j.cmet.2014.12.003. Cell Metab. 2015. PMID: 25565207 Free article.
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J. Bajzikova M, et al. Among authors: kluckova k. Cell Metab. 2019 Feb 5;29(2):399-416.e10. doi: 10.1016/j.cmet.2018.10.014. Epub 2018 Nov 15. Cell Metab. 2019. PMID: 30449682 Free PMC article.
Mitochondrial complex II, a novel target for anti-cancer agents.
Kluckova K, Bezawork-Geleta A, Rohlena J, Dong L, Neuzil J. Kluckova K, et al. Biochim Biophys Acta. 2013 May;1827(5):552-64. doi: 10.1016/j.bbabio.2012.10.015. Epub 2012 Nov 6. Biochim Biophys Acta. 2013. PMID: 23142170 Free article. Review.
Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis.
Truksa J, Dong LF, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J. Truksa J, et al. Among authors: kluckova k. Antioxid Redox Signal. 2015 Apr 10;22(11):883-900. doi: 10.1089/ars.2013.5594. Epub 2015 Feb 25. Antioxid Redox Signal. 2015. PMID: 25578105
Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II.
Dong LF, Jameson VJ, Tilly D, Cerny J, Mahdavian E, Marín-Hernández A, Hernández-Esquivel L, Rodríguez-Enríquez S, Stursa J, Witting PK, Stantic B, Rohlena J, Truksa J, Kluckova K, Dyason JC, Ledvina M, Salvatore BA, Moreno-Sánchez R, Coster MJ, Ralph SJ, Smith RA, Neuzil J. Dong LF, et al. Among authors: kluckova k. J Biol Chem. 2011 Feb 4;286(5):3717-28. doi: 10.1074/jbc.M110.186643. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059645 Free PMC article.
Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing.
Rohlena J, Dong LF, Kluckova K, Zobalova R, Goodwin J, Tilly D, Stursa J, Pecinova A, Philimonenko A, Hozak P, Banerjee J, Ledvina M, Sen CK, Houstek J, Coster MJ, Neuzil J. Rohlena J, et al. Among authors: kluckova k. Antioxid Redox Signal. 2011 Dec 15;15(12):2923-35. doi: 10.1089/ars.2011.4192. Antioxid Redox Signal. 2011. PMID: 21902599 Free PMC article.
Corrigendum to: "Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy" [Free Radic Biol Med. 50 (2011) 1546-1555].
Dong LF, Jameson VJA, Tilly D, Prochazka L, Rohlena J, Valis K, Truksa J, Zobalova R, Mahdavian E, Kluckova K, Stantic M, Stursa J, Freeman R, Witting PK, Norberg E, Goodwin J, Salvatore BA, Novotna J, Turanek J, Ledvina M, Hozak P, Zhivotovsky B, Coster MJ, Ralph SJ, Smith RAJ, Neuzil J. Dong LF, et al. Among authors: kluckova k. Free Radic Biol Med. 2013 Dec;65:895-896. doi: 10.1016/j.freeradbiomed.2013.08.164. Epub 2013 Aug 29. Free Radic Biol Med. 2013. PMID: 30184722 No abstract available.
36 results