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A Brief Background on Cannabis: From Plant to Medical Indications.

Klumpers LE, Thacker DL. Klumpers LE, et al. J AOAC Int. 2019 Mar 1;102(2):412-420. doi: 10.5740/jaoacint.18-0208. Epub 2018 Aug 23. J AOAC Int. 2019. PMID: 30139415 Review.

Pharmacokinetic/pharmaco-dynamic modelling and simulation of the effects of different cannabinoid receptor type 1 antagonists on Δ(9)-tetrahydrocannabinol challenge tests.

Guan Z, Klumpers LE, Oyetayo OO, Heuberger J, van Gerven JM, Stevens J. Guan Z, et al. Among authors: klumpers le. Br J Clin Pharmacol. 2016 Apr;81(4):713-23. doi: 10.1111/bcp.12852. Epub 2016 Jan 29. Br J Clin Pharmacol. 2016. PMID: 26617196 Free PMC article.

Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects.

Klumpers LE, Fridberg M, de Kam ML, Little PB, Jensen NO, Kleinloog HD, Elling CE, van Gerven JM. Klumpers LE, et al. Br J Clin Pharmacol. 2013 Dec;76(6):846-57. doi: 10.1111/bcp.12141. Br J Clin Pharmacol. 2013. PMID: 23601084 Free PMC article. Clinical Trial.

Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits Δ9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans.

Klumpers LE, Roy C, Ferron G, Turpault S, Poitiers F, Pinquier JL, van Hasselt JG, Zuurman L, Erwich FA, van Gerven JM. Klumpers LE, et al. Br J Clin Pharmacol. 2013 Jul;76(1):65-77. doi: 10.1111/bcp.12071. Br J Clin Pharmacol. 2013. PMID: 23278647 Free PMC article. Clinical Trial.

Manipulating brain connectivity with δ⁹-tetrahydrocannabinol: a pharmacological resting state FMRI study.

Klumpers LE, Cole DM, Khalili-Mahani N, Soeter RP, Te Beek ET, Rombouts SA, van Gerven JM. Klumpers LE, et al. Neuroimage. 2012 Nov 15;63(3):1701-11. doi: 10.1016/j.neuroimage.2012.07.051. Epub 2012 Aug 1. Neuroimage. 2012. PMID: 22885247 Clinical Trial.

Novel Δ(9) -tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects.

Klumpers LE, Beumer TL, van Hasselt JG, Lipplaa A, Karger LB, Kleinloog HD, Freijer JI, de Kam ML, van Gerven JM. Klumpers LE, et al. Br J Clin Pharmacol. 2012 Jul;74(1):42-53. doi: 10.1111/j.1365-2125.2012.04164.x. Br J Clin Pharmacol. 2012. PMID: 22680341 Free PMC article. Clinical Trial.

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