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ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C. Zheng G, et al. Among authors: klungland a. Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012 Nov 21. Mol Cell. 2013. PMID: 23177736 Free PMC article.
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG. Li MM, et al. Among authors: klungland a. Nat Commun. 2013;4:1832. doi: 10.1038/ncomms2863. Nat Commun. 2013. PMID: 23673617 Free PMC article.
Dynamic RNA modifications in disease.
Klungland A, Dahl JA. Klungland A, et al. Curr Opin Genet Dev. 2014 Jun;26:47-52. doi: 10.1016/j.gde.2014.05.006. Epub 2014 Jul 5. Curr Opin Genet Dev. 2014. PMID: 25005745 Review.
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB. Ke S, et al. Among authors: klungland a. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24. Genes Dev. 2015. PMID: 26404942 Free PMC article.
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice.
Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjørås M, Klungland A. Li M, et al. Among authors: klungland a. Genome Biol. 2018 May 31;19(1):69. doi: 10.1186/s13059-018-1436-y. Genome Biol. 2018. PMID: 29855337 Free PMC article.
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Zhang LS, Xiong QP, Peña Perez S, Liu C, Wei J, Le C, Zhang L, Harada BT, Dai Q, Feng X, Hao Z, Wang Y, Dong X, Hu L, Wang ED, Pan T, Klungland A, Liu RJ, He C. Zhang LS, et al. Among authors: klungland a. Nat Cell Biol. 2021 Jul;23(7):684-691. doi: 10.1038/s41556-021-00709-7. Epub 2021 Jul 12. Nat Cell Biol. 2021. PMID: 34253897 Free PMC article.
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
Songe-Møller L, van den Born E, Leihne V, Vågbø CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PØ, Klungland A. Songe-Møller L, et al. Among authors: klungland a. Mol Cell Biol. 2010 Apr;30(7):1814-27. doi: 10.1128/MCB.01602-09. Epub 2010 Feb 1. Mol Cell Biol. 2010. PMID: 20123966 Free PMC article.
151 results