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Titin splicing regulates cardiotoxicity associated with calpain 3 gene therapy for limb-girdle muscular dystrophy type 2A.
Lostal W, Roudaut C, Faivre M, Charton K, Suel L, Bourg N, Best H, Smith JE, Gohlke J, Corre G, Li X, Elbeck Z, Knöll R, Deschamps JY, Granzier H, Richard I. Lostal W, et al. Among authors: knoll r. Sci Transl Med. 2019 Nov 27;11(520):eaat6072. doi: 10.1126/scitranslmed.aat6072. Sci Transl Med. 2019. PMID: 31776291 Free PMC article.
The Degree of Cardiac Remodelling before Overload Relief Triggers Different Transcriptome and miRome Signatures during Reverse Remodelling (RR)-Molecular Signature Differ with the Extent of RR.
Rodrigues PG, Miranda-Silva D, Li X, Sousa-Mendes C, Martins-Ferreira R, Elbeck Z, Leite-Moreira AF, Knöll R, Falcão-Pires I. Rodrigues PG, et al. Among authors: knoll r. Int J Mol Sci. 2020 Dec 18;21(24):9687. doi: 10.3390/ijms21249687. Int J Mol Sci. 2020. PMID: 33353134 Free PMC article.
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, Boogerd CJ, Frisk M, van Rooij E, Damle S, Louch WE, Wang QD, Fritsche-Danielson R, Chien KR, Hansson KM, Mullick AE, de Boer RA, van der Meer P. Grote Beverborg N, et al. Among authors: knoll r. Nat Commun. 2021 Aug 30;12(1):5180. doi: 10.1038/s41467-021-25439-0. Nat Commun. 2021. PMID: 34462437 Free PMC article.
Cell shape determines gene expression: cardiomyocyte morphotypic transcriptomes.
Haftbaradaran Esfahani P, ElBeck Z, Sagasser S, Li X, Hossain MB, Talukdar HA, Sandberg R, Knöll R. Haftbaradaran Esfahani P, et al. Among authors: knoll r. Basic Res Cardiol. 2019 Dec 23;115(1):7. doi: 10.1007/s00395-019-0765-7. Basic Res Cardiol. 2019. PMID: 31872302 Free PMC article.
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin A, Gärtner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, Folsche L, Hobbach AJ, von Frieling-Salewsky M, Unger A, Hucke A, Koser F, Kassner A, Sielemann K, Streckfuß-Bömeke K, Hasenfuss G, Goedel A, Laugwitz KL, Moretti A, Gummert JF, Dos Remedios CG, Reinecke H, Knöll R, van Heesch S, Hubner N, Zimmermann WH, Milting H, Linke WA. Fomin A, et al. Among authors: knoll r. Sci Transl Med. 2021 Nov 3;13(618):eabd3079. doi: 10.1126/scitranslmed.abd3079. Epub 2021 Nov 3. Sci Transl Med. 2021. PMID: 34731013
187 results