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O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies.
Huang Z, Kaur J, Bhardwaj A, Alsaleh N, Reisz JA, DuMond JF, King SB, Seubert JM, Zhang Y, Knaus EE. Huang Z, et al. Among authors: knaus ee. J Med Chem. 2012 Nov 26;55(22):10262-71. doi: 10.1021/jm301303p. Epub 2012 Oct 24. J Med Chem. 2012. PMID: 23072318
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.
Chowdhury MA, Abdellatif KR, Dong Y, Yu G, Huang Z, Rahman M, Das D, Velázquez CA, Suresh MR, Knaus EE. Chowdhury MA, et al. Among authors: knaus ee. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1324-9. doi: 10.1016/j.bmcl.2010.01.014. Epub 2010 Jan 11. Bioorg Med Chem Lett. 2010. PMID: 20097072
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Yu G, Chowdhury MA, Abdellatif KR, Dong Y, Praveen Rao PN, Das D, Velázquez CA, Suresh MR, Knaus EE. Yu G, et al. Among authors: knaus ee. Bioorg Med Chem Lett. 2010 Feb 1;20(3):896-902. doi: 10.1016/j.bmcl.2009.12.073. Epub 2009 Dec 23. Bioorg Med Chem Lett. 2010. PMID: 20045320
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.
Abdellatif KR, Chowdhury MA, Dong Y, Das D, Yu G, Velázquez C, Suresh MR, Knaus EE. Abdellatif KR, et al. Among authors: knaus ee. Bioorg Med Chem. 2009 Jul 15;17(14):5182-8. doi: 10.1016/j.bmc.2009.05.046. Epub 2009 May 27. Bioorg Med Chem. 2009. PMID: 19500994
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.
Abdellatif KR, Chowdhury MA, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE. Abdellatif KR, et al. Among authors: knaus ee. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3014-8. doi: 10.1016/j.bmcl.2009.04.059. Epub 2009 Apr 20. Bioorg Med Chem Lett. 2009. PMID: 19419861
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE. Chowdhury MA, et al. Among authors: knaus ee. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6138-41. doi: 10.1016/j.bmcl.2008.10.009. Epub 2008 Oct 7. Bioorg Med Chem Lett. 2008. PMID: 18945614
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.
Abdellatif KR, Chowdhury MA, Dong Y, Velázquez C, Das D, Suresh MR, Knaus EE. Abdellatif KR, et al. Among authors: knaus ee. Bioorg Med Chem. 2008 Nov 15;16(22):9694-8. doi: 10.1016/j.bmc.2008.10.001. Epub 2008 Oct 5. Bioorg Med Chem. 2008. PMID: 18930406
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