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Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae.
Naesby M, Nielsen SV, Nielsen CA, Green T, Tange TO, Simón E, Knechtle P, Hansson A, Schwab MS, Titiz O, Folly C, Archila RE, Maver M, van Sint Fiet S, Boussemghoune T, Janes M, Kumar AS, Sonkar SP, Mitra PP, Benjamin VA, Korrapati N, Suman I, Hansen EH, Thybo T, Goldsmith N, Sorensen AS. Naesby M, et al. Among authors: knechtle p. Microb Cell Fact. 2009 Aug 13;8:45. doi: 10.1186/1475-2859-8-45. Microb Cell Fact. 2009. PMID: 19678954 Free PMC article.
The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis.
Knechtle P, Diefenbacher M, Greve KB, Brianza F, Folly C, Heider H, Lone MA, Long L, Meyer JP, Roussel P, Ghannoum MA, Schneiter R, Sorensen AS. Knechtle P, et al. Antimicrob Agents Chemother. 2014;58(1):455-66. doi: 10.1128/AAC.01443-13. Epub 2013 Nov 4. Antimicrob Agents Chemother. 2014. PMID: 24189258 Free PMC article.
Intrapulmonary Pharmacokinetics of Cefepime and Enmetazobactam in Healthy Volunteers: Towards New Treatments for Nosocomial Pneumonia.
Das S, Fitzgerald R, Ullah A, Bula M, Collins AM, Mitsi E, Reine J, Hill H, Rylance J, Ferreira DM, Tripp K, Bertasini A, Franzoni S, Massimiliano M, Lahlou O, Motta P, Barth P, Velicitat P, Knechtle P, Hope W. Das S, et al. Among authors: knechtle p. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01468-20. doi: 10.1128/AAC.01468-20. Print 2020 Dec 16. Antimicrob Agents Chemother. 2020. PMID: 33077666 Free PMC article.
Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum-β-Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae.
Johnson A, McEntee L, Farrington N, Kolamunnage-Dona R, Franzoni S, Vezzelli A, Massimiliano M, Knechtle P, Belley A, Dane A, Drusano G, Das S, Hope W. Johnson A, et al. Among authors: knechtle p. Antimicrob Agents Chemother. 2020 May 21;64(6):e00180-20. doi: 10.1128/AAC.00180-20. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32253209 Free PMC article.
Third-generation cephalosporin resistance in clinical isolates of Enterobacterales collected between 2016-2018 from USA and Europe: genotypic analysis of β-lactamases and comparative in vitro activity of cefepime/enmetazobactam.
Belley A, Morrissey I, Hawser S, Kothari N, Knechtle P. Belley A, et al. Among authors: knechtle p. J Glob Antimicrob Resist. 2021 Jun;25:93-101. doi: 10.1016/j.jgar.2021.02.031. Epub 2021 Mar 18. J Glob Antimicrob Resist. 2021. PMID: 33746112 Free article.
Development of Broth Microdilution MIC and Disk Diffusion Antimicrobial Susceptibility Test Quality Control Ranges for the Combination of Cefepime and the Novel β-Lactamase Inhibitor Enmetazobactam.
Belley A, Huband MD, Fedler KA, Watters AA, Flamm RK, Shapiro S, Knechtle P. Belley A, et al. Among authors: knechtle p. J Clin Microbiol. 2019 Jul 26;57(8):e00607-19. doi: 10.1128/JCM.00607-19. Print 2019 Aug. J Clin Microbiol. 2019. PMID: 31167844 Free PMC article.
Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial.
Kaye KS, Belley A, Barth P, Lahlou O, Knechtle P, Motta P, Velicitat P. Kaye KS, et al. Among authors: knechtle p. JAMA. 2022 Oct 4;328(13):1304-1314. doi: 10.1001/jama.2022.17034. JAMA. 2022. PMID: 36194218 Free PMC article. Clinical Trial.
131 results