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Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction.
Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B. Wehmeyer C, et al. Among authors: kneissel m. Sci Transl Med. 2016 Mar 16;8(330):330ra35. doi: 10.1126/scitranslmed.aac4351. Epub 2016 Mar 16. Sci Transl Med. 2016. PMID: 27089204
Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis.
Kramer I, Halleux C, Keller H, Pegurri M, Gooi JH, Weber PB, Feng JQ, Bonewald LF, Kneissel M. Kramer I, et al. Among authors: kneissel m. Mol Cell Biol. 2010 Jun;30(12):3071-85. doi: 10.1128/MCB.01428-09. Epub 2010 Apr 19. Mol Cell Biol. 2010. PMID: 20404086 Free PMC article.
The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis.
Fairfield H, Falank C, Harris E, Demambro V, McDonald M, Pettitt JA, Mohanty ST, Croucher P, Kramer I, Kneissel M, Rosen CJ, Reagan MR. Fairfield H, et al. Among authors: kneissel m. J Cell Physiol. 2018 Feb;233(2):1156-1167. doi: 10.1002/jcp.25976. Epub 2017 Jun 6. J Cell Physiol. 2018. PMID: 28460416 Free PMC article.
Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.
Leupin O, Piters E, Halleux C, Hu S, Kramer I, Morvan F, Bouwmeester T, Schirle M, Bueno-Lozano M, Fuentes FJ, Itin PH, Boudin E, de Freitas F, Jennes K, Brannetti B, Charara N, Ebersbach H, Geisse S, Lu CX, Bauer A, Van Hul W, Kneissel M. Leupin O, et al. Among authors: kneissel m. J Biol Chem. 2011 Jun 3;286(22):19489-500. doi: 10.1074/jbc.M110.190330. Epub 2011 Apr 6. J Biol Chem. 2011. PMID: 21471202 Free PMC article.
Dental and periodontal phenotype in sclerostin knockout mice.
Kuchler U, Schwarze UY, Dobsak T, Heimel P, Bosshardt DD, Kneissel M, Gruber R. Kuchler U, et al. Among authors: kneissel m. Int J Oral Sci. 2014 Jun;6(2):70-6. doi: 10.1038/ijos.2014.12. Epub 2014 Apr 4. Int J Oral Sci. 2014. PMID: 24699186 Free PMC article.
70 results