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A Broad-Spectrum Inhibitor of CRISPR-Cas9.
Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. Harrington LB, et al. Among authors: Knott GJ. Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24. Cell. 2017. PMID: 28844692 Free PMC article.
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.
East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA. East-Seletsky A, et al. Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008. Mol Cell. 2017. PMID: 28475872 Free PMC article.
Structures of the CRISPR genome integration complex.
Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA. Wright AV, et al. Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20. Science. 2017. PMID: 28729350 Free PMC article.
Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA. Knott GJ, et al. Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11. Nat Struct Mol Biol. 2017. PMID: 28892041 Free PMC article.
RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.
Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR. Tambe A, et al. Among authors: Knott GJ. Cell Rep. 2018 Jul 24;24(4):1025-1036. doi: 10.1016/j.celrep.2018.06.105. Cell Rep. 2018. PMID: 30044970 Free PMC article.
CRISPR-Cas guides the future of genetic engineering.
Knott GJ, Doudna JA. Knott GJ, et al. Science. 2018 Aug 31;361(6405):866-869. doi: 10.1126/science.aat5011. Science. 2018. PMID: 30166482 Free PMC article. Review.
CasX enzymes comprise a distinct family of RNA-guided genome editors.
Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA. Liu JJ, et al. Among authors: Knott GJ. Nature. 2019 Feb;566(7743):218-223. doi: 10.1038/s41586-019-0908-x. Epub 2019 Feb 4. Nature. 2019. PMID: 30718774 Free PMC article.
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a.
Knott GJ, Thornton BW, Lobba MJ, Liu JJ, Al-Shayeb B, Watters KE, Doudna JA. Knott GJ, et al. Nat Struct Mol Biol. 2019 Apr;26(4):315-321. doi: 10.1038/s41594-019-0208-z. Epub 2019 Apr 1. Nat Struct Mol Biol. 2019. PMID: 30936531 Free PMC article.
Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Knott GJ, et al. Elife. 2019 Aug 9;8:e49110. doi: 10.7554/eLife.49110. Elife. 2019. PMID: 31397669 Free PMC article.
Machine learning predicts new anti-CRISPR proteins.
Eitzinger S, Asif A, Watters KE, Iavarone AT, Knott GJ, Doudna JA, Minhas FUAA. Eitzinger S, et al. Among authors: Knott GJ. Nucleic Acids Res. 2020 May 21;48(9):4698-4708. doi: 10.1093/nar/gkaa219. Nucleic Acids Res. 2020. PMID: 32286628 Free PMC article.
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