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Frequency analysis of tumor-reactive cytotoxic T lymphocytes in peripheral blood of a melanoma patient vaccinated with autologous tumor cells.
Herr W, Wölfel T, Heike M, Meyer zum Büschenfelde KH, Knuth A. Herr W, et al. Cancer Immunol Immunother. 1994 Aug;39(2):93-9. doi: 10.1007/BF01525314. Cancer Immunol Immunother. 1994. PMID: 8044834
A limiting-dilution assay was developed and used to determine the frequency of autologous tumor-reactive cytotoxic T lymphocytes (CTL) in peripheral blood of a melanoma patient MZ2, who has been free of detectable disease since several years. In this patient, the fr
A limiting-dilution assay was developed and used to determine the frequency of autologous tumor-reactive cytotoxic T lymphocytes (CTL
Lysis of human pancreatic adenocarcinoma cells by autologous HLA-class I-restricted cytolytic T-lymphocyte (CTL) clones.
Wölfel T, Herr W, Coulie P, Schmitt U, Meyer zum Büschenfelde KH, Knuth A. Wölfel T, et al. Int J Cancer. 1993 Jun 19;54(4):636-44. doi: 10.1002/ijc.2910540419. Int J Cancer. 1993. PMID: 8514455
From the primary site of a pancreatic adenocarcinoma (patient BE) a permanent cell line (MZ-PC-2) was established in tissue culture. ...They all expressed the same TCR-beta chain, indicating that they descended from a common precursor lymphocyte and were dire …
From the primary site of a pancreatic adenocarcinoma (patient BE) a permanent cell line (MZ-PC-2) was established in tissue cu …
Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.
Knuth A, Wölfel T, Klehmann E, Boon T, Meyer zum Büschenfelde KH. Knuth A, et al. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2804-8. doi: 10.1073/pnas.86.8.2804. Proc Natl Acad Sci U S A. 1989. PMID: 2784858 Free PMC article.
T cell responses to human malignant tumours.
Knuth A, Wölfel T, Meyer zum Büschenfelde KH. Knuth A, et al. Cancer Surv. 1992;13:39-52. Cancer Surv. 1992. PMID: 1423325 Review.
The immunological and molecular mechanisms that govern T cell responses to human malignant tumours are just starting to be understood within a more complex framework of humoral, cellular and molecular interactions. The definition of multiple antigens simultaneously express …
The immunological and molecular mechanisms that govern T cell responses to human malignant tumours are just starting to be understood within …
A human renal cancer line as a new antigen source for the detection of antibodies to cytoplasmic and nuclear antigens in sera of patients with Wegener's granulomatosis.
Mayet WJ, Hermann E, Csernok E, Knuth A, Poralla T, Gross WL, Meyer zum Büschenfelde KH. Mayet WJ, et al. J Immunol Methods. 1991 Sep 20;143(1):57-68. doi: 10.1016/0022-1759(91)90272-h. J Immunol Methods. 1991. PMID: 1717605
A protein of 29 kDa MW could be isolated by affinity purification using a SK-RC11 extract and a high-titer C-ANCA+ serum and antigenic identity was further confirmed by IFT using a monoclonal antibody to proteinase 3. Treatment of tumor cells with cyto
A protein of 29 kDa MW could be isolated by affinity purification using a SK-RC11 extract and a high-titer C-ANCA+ seru
Gene transfer of the Co-stimulatory molecules B7-1 and B7-2 enhances the immunogenicity of human renal cell carcinoma to a different extent.
Jung D, Hilmes C, Knuth A, Jaeger E, Huber C, Seliger B. Jung D, et al. Scand J Immunol. 1999 Sep;50(3):242-9. doi: 10.1046/j.1365-3083.1999.00588.x. Scand J Immunol. 1999. PMID: 10447932
Stimulation of a specific antitumour immune response with recruitment and induction of T-cell effector functions represents an attractive concept in human cancer therapy. ...The lack of B7 expression was associated with a low or absent proliferative response of allo …
Stimulation of a specific antitumour immune response with recruitment and induction of T-cell effector functions represents an attrac …
Induction of immunogenicity of a human renal-cell carcinoma cell line by TAP1-gene transfer.
Kallfelz M, Jung D, Hilmes C, Knuth A, Jaeger E, Huber C, Seliger B. Kallfelz M, et al. Int J Cancer. 1999 Mar 31;81(1):125-33. doi: 10.1002/(sici)1097-0215(19990331)81:1<125::aid-ijc21>3.0.co;2-2. Int J Cancer. 1999. PMID: 10077163
While the TAP1 transfectants showed heterogeneous TAP1-transgene expression pattern of mRNA and protein, high TAP1 expression and a TAP-controlled increase in MHC-class-I surface expression could be achieved in selected transfectants. IFN-gamma up-regulates the expression …
While the TAP1 transfectants showed heterogeneous TAP1-transgene expression pattern of mRNA and protein, high TAP1 expression and a T …
Strong immunogenic potential of a B7 retroviral expression vector: generation of HLA-B7-restricted CTL response against selectable marker genes.
Jung D, Jaeger E, Cayeux S, Blankenstein T, Hilmes C, Karbach J, Moebius U, Knuth A, Huber C, Seliger B. Jung D, et al. Hum Gene Ther. 1998 Jan 1;9(1):53-62. doi: 10.1089/hum.1998.9.1-53. Hum Gene Ther. 1998. PMID: 9458242
In this study, human renal cell carcinoma cell lines were modified by a retrovirus to express the co-stimulatory molecule B7-1 together with the hygromycin/thymidine kinase fusion protein (HygTk) as positive and negative selection markers. ...Evidence for a strong v …
In this study, human renal cell carcinoma cell lines were modified by a retrovirus to express the co-stimulatory molecule B7-1 togeth …
Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes.
Jäger E, Chen YT, Drijfhout JW, Karbach J, Ringhoffer M, Jäger D, Arand M, Wada H, Noguchi Y, Stockert E, Old LJ, Knuth A. Jäger E, et al. J Exp Med. 1998 Jan 19;187(2):265-70. doi: 10.1084/jem.187.2.265. J Exp Med. 1998. PMID: 9432985 Free PMC article.
A growing number of human tumor antigens have been described that can be recognized by cytotoxic T lymphocytes (CTLs) in a major histocompatibility complex (MHC) class I-restricted fashion. ...In this paper, we report on a melanoma patient with a high-
A growing number of human tumor antigens have been described that can be recognized by cytotoxic T lymphocytes (CTLs) in a maj
Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression.
Seliger B, Hohne A, Knuth A, Bernhard H, Meyer T, Tampe R, Momburg F, Huber C. Seliger B, et al. Cancer Res. 1996 Apr 15;56(8):1756-60. Cancer Res. 1996. PMID: 8620489
Using normal epithelial kidney cells (MZ1851NN) and renal cell carcinoma cell lines established from the primary tumor (MZ1851RC) and a lymph node metastasis (MZ1851LN) of the same patient, we investigated whether the modulation of MHC class I antigens, TAP and LMP molecul …
Using normal epithelial kidney cells (MZ1851NN) and renal cell carcinoma cell lines established from the primary tumor (MZ1851RC) and a
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