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JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors.
Irey EA, Lassiter CM, Brady NJ, Chuntova P, Wang Y, Knutson TP, Henzler C, Chaffee TS, Vogel RI, Nelson AC, Farrar MA, Schwertfeger KL. Irey EA, et al. Among authors: knutson tp. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12442-12451. doi: 10.1073/pnas.1816410116. Epub 2019 May 30. Proc Natl Acad Sci U S A. 2019. PMID: 31147469 Free PMC article.
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.
Mitchell JS, Spanier JA, Dwyer AJ, Knutson TP, Alkhatib MH, Qian G, Weno ME, Chen Y, Shaheen ZR, Tucker CG, Kangas TO, Morales MS, Silva N, Kaisho T, Farrar MA, Fife BT. Mitchell JS, et al. Among authors: knutson tp. Immunity. 2024 Oct 8;57(10):2399-2415.e8. doi: 10.1016/j.immuni.2024.07.024. Epub 2024 Aug 29. Immunity. 2024. PMID: 39214091
CD8+ T cell self-tolerance permits responsiveness but limits tissue damage.
Truckenbrod EN, Burrack KS, Knutson TP, Borges da Silva H, Block KE, O'Flanagan SD, Stagliano KR, Hurwitz AA, Fulton RB, Renkema KR, Jameson SC. Truckenbrod EN, et al. Among authors: knutson tp. Elife. 2021 Apr 30;10:e65615. doi: 10.7554/eLife.65615. Elife. 2021. PMID: 33929324 Free PMC article.
Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of κB Kinase ϵ and Inflammatory Cross-talk with Macrophages.
Girard BJ, Knutson TP, Kuker B, McDowell L, Schwertfeger KL, Ostrander JH. Girard BJ, et al. Among authors: knutson tp. J Biol Chem. 2017 Jan 6;292(1):339-350. doi: 10.1074/jbc.M116.739847. Epub 2016 Nov 23. J Biol Chem. 2017. PMID: 27881676 Free PMC article.
46 results