Genetic variants in C5 and poor response to eculizumab.
Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Brodsky AL, Noji H, Kitamura K, Eto T, Takahashi T, Masuko M, Matsumoto T, Wano Y, Shichishima T, Shibayama H, Hase M, Li L, Johnson K, Lazarowski A, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y.
Nishimura J, et al.
N Engl J Med. 2014 Feb 13;370(7):632-9. doi: 10.1056/NEJMoa1311084.
N Engl J Med. 2014.
PMID: 24521109
Free article.
All 11 had a single missense C5 heterozygous mutation, c.2654G A, which predicts the polymorphism p.Arg885His. ...In vitro hemolysis due to nonmutant and mutant C5 was completely blocked with the use of N19-8, a monoclonal antibody that binds to a different site on …
All 11 had a single missense C5 heterozygous mutation, c.2654G A, which predicts the polymorphism p.Arg885His. ...In vitro hemolysis …