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Page 1
Amiloride Reduces Urokinase/Plasminogen-Driven Intratubular Complement Activation in Glomerular Proteinuria.
Isaksson GL, Hinrichs GR, Andersen H, Bach ML, Weyer K, Zachar R, Henriksen JE, Madsen K, Lund IK, Mollet G, Bistrup C, Birn H, Jensen BL, Palarasah Y. Isaksson GL, et al. J Am Soc Nephrol. 2024 Apr 1;35(4):410-425. doi: 10.1681/ASN.0000000000000312. Epub 2024 Jan 23. J Am Soc Nephrol. 2024. PMID: 38254266
We hypothesized that plasmin activates filtered complement factors C3 and C5 directly in tubular fluid, generating anaphylatoxins, and that this is attenuated by amiloride, an off-target uPA inhibitor. METHODS: Purified C3, C5, plasminogen, urokinase, and urine from …
We hypothesized that plasmin activates filtered complement factors C3 and C5 directly in tubular fluid, generating anaphylatoxins, an …
Search for Higgs Boson Decay to a Charm Quark-Antiquark Pair in Proton-Proton Collisions at sqrt[s]=13  TeV.
Tumasyan A, Adam W, Andrejkovic JW, Bergauer T, Chatterjee S, Damanakis K, Dragicevic M, Escalante Del Valle A, Hussain PS, Jeitler M, Krammer N, Lechner L, Liko D, Mikulec I, Paulitsch P, Pitters FM, Schieck J, Schöfbeck R, Schwarz D, Templ S, Waltenberger W, Wulz CE, Darwish MR, Janssen T, Kello T, Rejeb Sfar H, Van Mechelen P, Bols ES, D'Hondt J, De Moor A, Delcourt M, El Faham H, Lowette S, Moortgat S, Morton A, Müller D, Sahasransu AR, Tavernier S, Van Doninck W, Vannerom D, Clerbaux B, De Lentdecker G, Favart L, Jaramillo J, Lee K, Mahdavikhorrami M, Makarenko I, Malara A, Paredes S, Pétré L, Postiau N, Starling E, Thomas L, Vanden Bemden M, Vander Velde C, Vanlaer P, Dobur D, Knolle J, Lambrecht L, Mestdach G, Niedziela M, Rendón C, Roskas C, Samalan A, Skovpen K, Tytgat M, Van Den Bossche N, Vermassen B, Wezenbeek L, Benecke A, Bethani A, Bruno G, Bury F, Caputo C, David P, Delaere C, Donertas IS, Giammanco A, Jaffel K, Jain S, Lemaitre V, Mondal K, Prisciandaro J, Taliercio A, Tran TT, Vischia P, Wertz S, Alves GA, Coelho E, Hensel C, Moraes A, Rebello Teles P, Aldá Júnior WL, Alves Gallo Pereira M, Barroso Ferreira Filho M, Brandao Malbouisson H, Carvalho W, Chinellato J… See abstract for full author list ➔ Tumasyan A, et al. Phys Rev Lett. 2023 Aug 11;131(6):061801. doi: 10.1103/PhysRevLett.131.061801. Phys Rev Lett. 2023. PMID: 37625071
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects.
Kannan A, Suomalainen M, Volle R, Bauer M, Amsler M, Trinh HV, Vavassori S, Schmid JP, Vilhena G, Marín-González A, Perez R, Franceschini A, Mering CV, Hemmi S, Greber UF. Kannan A, et al. Viruses. 2022 Jun 28;14(7):1407. doi: 10.3390/v14071407. Viruses. 2022. PMID: 35891387 Free PMC article.
The inhibition of AdV-C5 infection with miR-29b-1* mimic depended on the IFN-alpha receptor 2 (IFNAR2) and the RNA-helicase retinoic acid-inducible gene I (RIG-I) but not cytoplasmic RNA sensors MDA5 and ZNFX1 or MyD88/TRIF adaptors. The antiviral effects of miR29b-1* were …
The inhibition of AdV-C5 infection with miR-29b-1* mimic depended on the IFN-alpha receptor 2 (IFNAR2) and the RNA-helicase retinoic …
A small-molecule inhibitor of PCSK9 transcription ameliorates atherosclerosis through the modulation of FoxO1/3 and HNF1α.
Wang X, Chen X, Zhang X, Su C, Yang M, He W, Du Y, Si S, Wang L, Hong B. Wang X, et al. EBioMedicine. 2020 Feb;52:102650. doi: 10.1016/j.ebiom.2020.102650. Epub 2020 Feb 12. EBioMedicine. 2020. PMID: 32058941 Free PMC article.
In both C57BL/6 J and ApoE KO mice, oral administration of 7030B-C5 reduced hepatic and plasma PCSK9 level and increased hepatic LDLR expression. Most importantly, 7030B-C5 inhibited lesions in en face aortas and aortic root in ApoE KO mice with a slig …
In both C57BL/6 J and ApoE KO mice, oral administration of 7030B-C5 reduced hepatic and plasma PCSK9 level and increased hepat …
Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries.
Liang C, Zhang Y, Zhuo D, Lo CY, Yu L, Lau CW, Kwan YW, Tse G, Huang Y, Yao X. Liang C, et al. Biochem Pharmacol. 2019 Jan;159:11-24. doi: 10.1016/j.bcp.2018.11.002. Epub 2018 Nov 7. Biochem Pharmacol. 2019. PMID: 30414390
Immunohistochemical staining found the expression of transient receptor potential channel C5 (TRPC5) in endothelial and smooth muscle cells of mouse carotid arteries. ACH-induced EDC in male mouse carotid arteries was found to be substantially reduced in TRPC5 knockout ( …
Immunohistochemical staining found the expression of transient receptor potential channel C5 (TRPC5) in endothelial and smooth muscle …
Brachial Plexus Ultrasound and MRI in Children with Brachial Plexus Birth Injury.
Gunes A, Bulut E, Uzumcugil A, Oguz KK. Gunes A, et al. AJNR Am J Neuroradiol. 2018 Sep;39(9):1745-1750. doi: 10.3174/ajnr.A5749. Epub 2018 Aug 9. AJNR Am J Neuroradiol. 2018. PMID: 30093478 Free PMC article.
BACKGROUND AND PURPOSE: Brachial plexus birth injury is caused by traction on the neck during delivery and results in flaccid palsy of an upper extremity commonly involving C5-C6 nerve roots. MR imaging and MR myelography help to assess the anatomic location, extent, and s …
BACKGROUND AND PURPOSE: Brachial plexus birth injury is caused by traction on the neck during delivery and results in flaccid palsy of an up …
Steroidal Glucosides from the Rhizomes of Tacca chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells.
Yen PH, Chi VT, Kim DC, Ko W, Oh H, Kim YC, Dung DT, Thanh NT, Quang TH, Ngan NT, Nhiema NX, Anh Hle T, Minh CV, Kiem PV. Yen PH, et al. Nat Prod Commun. 2016 Jan;11(1):45-8. Nat Prod Commun. 2016. PMID: 26996017
Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4), chantriolide C (5), and (25S)-spirost-5-en-3-ol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L-rhamnopyranosyl-(1-->3)]-beta-D-gluc …
Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4 …
Two new compounds and anti-complementary constituents from Amomum tsao-ko.
Jin J, Cheng Z, Chen D. Jin J, et al. Nat Prod Commun. 2013 Dec;8(12):1715-8. Nat Prod Commun. 2013. PMID: 24555280
Two new compounds, (2R,3R,4R)-3',5'-dimethoxy-3,4,7,4'-tetrahydroxy-flavan (1) and 2-(4-hydroxy-3-methoxybenzoyl)-4-methoxy-benzaldehyde (2), together with 35 known phenolic compounds were obtained from the fruits of Amomum tsao-ko. Structures of the new compounds were elu …
Two new compounds, (2R,3R,4R)-3',5'-dimethoxy-3,4,7,4'-tetrahydroxy-flavan (1) and 2-(4-hydroxy-3-methoxybenzoyl)-4-methoxy-benzaldehyde (2) …
Genetic variants in C5 and poor response to eculizumab.
Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Brodsky AL, Noji H, Kitamura K, Eto T, Takahashi T, Masuko M, Matsumoto T, Wano Y, Shichishima T, Shibayama H, Hase M, Li L, Johnson K, Lazarowski A, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y. Nishimura J, et al. N Engl J Med. 2014 Feb 13;370(7):632-9. doi: 10.1056/NEJMoa1311084. N Engl J Med. 2014. PMID: 24521109 Free article.
All 11 had a single missense C5 heterozygous mutation, c.2654G A, which predicts the polymorphism p.Arg885His. ...In vitro hemolysis due to nonmutant and mutant C5 was completely blocked with the use of N19-8, a monoclonal antibody that binds to a different site on …
All 11 had a single missense C5 heterozygous mutation, c.2654G A, which predicts the polymorphism p.Arg885His. ...In vitro hemolysis …
Spinal cord injury incurred by neck massage.
Cheong HS, Hong BY, Ko YA, Lim SH, Kim JS. Cheong HS, et al. Ann Rehabil Med. 2012 Oct;36(5):708-12. doi: 10.5535/arm.2012.36.5.708. Epub 2012 Oct 31. Ann Rehabil Med. 2012. PMID: 23185737 Free PMC article.
Imaging studies revealed compressive myelopathy at the C6 level, ossification of the posterior longitudinal ligament (OPLL), and a herniated nucleus pulposus (HNP) at the C5-6 level. After 3 years of rehabilitation, his motor power improved, and he is able to walk and driv …
Imaging studies revealed compressive myelopathy at the C6 level, ossification of the posterior longitudinal ligament (OPLL), and a herniated …
12 results