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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.
Pethe K, Bifani P, Jang J, Kang S, Park S, Ahn S, Jiricek J, Jung J, Jeon HK, Cechetto J, Christophe T, Lee H, Kempf M, Jackson M, Lenaerts AJ, Pham H, Jones V, Seo MJ, Kim YM, Seo M, Seo JJ, Park D, Ko Y, Choi I, Kim R, Kim SY, Lim S, Yim SA, Nam J, Kang H, Kwon H, Oh CT, Cho Y, Jang Y, Kim J, Chua A, Tan BH, Nanjundappa MB, Rao SP, Barnes WS, Wintjens R, Walker JR, Alonso S, Lee S, Kim J, Oh S, Oh T, Nehrbass U, Han SJ, No Z, Lee J, Brodin P, Cho SN, Nam K, Kim J. Pethe K, et al. Among authors: ko y. Nat Med. 2013 Sep;19(9):1157-60. doi: 10.1038/nm.3262. Epub 2013 Aug 4. Nat Med. 2013. PMID: 23913123 Free article.
Lead optimization of a novel series of imidazo[1,2-a]pyridine amides leading to a clinical candidate (Q203) as a multi- and extensively-drug-resistant anti-tuberculosis agent.
Kang S, Kim RY, Seo MJ, Lee S, Kim YM, Seo M, Seo JJ, Ko Y, Choi I, Jang J, Nam J, Park S, Kang H, Kim HJ, Kim J, Ahn S, Pethe K, Nam K, No Z, Kim J. Kang S, et al. Among authors: ko y. J Med Chem. 2014 Jun 26;57(12):5293-305. doi: 10.1021/jm5003606. Epub 2014 Jun 17. J Med Chem. 2014. PMID: 24870926
Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors.
Kim J, Kwon J, Lee D, Jo S, Park DS, Choi J, Park E, Hwang JY, Ko Y, Choi I, Ju MK, Ahn J, Kim J, Han SJ, Kim TH, Cechetto J, Nam J, Ahn S, Sommer P, Liuzzi M, No Z, Lee J. Kim J, et al. Among authors: ko y. Bioorg Med Chem Lett. 2013 Jan 1;23(1):153-7. doi: 10.1016/j.bmcl.2012.10.134. Epub 2012 Nov 12. Bioorg Med Chem Lett. 2013. PMID: 23206860
Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.
Kim J, Lee D, Park C, So W, Jo M, Ok T, Kwon J, Kong S, Jo S, Kim Y, Choi J, Kim HC, Ko Y, Choi I, Park Y, Yoon J, Ju MK, Kim J, Han SJ, Kim TH, Cechetto J, Nam J, Sommer P, Liuzzi M, Lee J, No Z. Kim J, et al. Among authors: ko y. ACS Med Chem Lett. 2012 Jul 11;3(8):678-82. doi: 10.1021/ml300146q. eCollection 2012 Aug 9. ACS Med Chem Lett. 2012. PMID: 24900529 Free PMC article.
Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors.
Kim J, Kwon J, Lee D, Jo S, Park DS, Choi J, Park E, Hwang JY, Ko Y, Choi I, Ju MK, Ahn J, Kim J, Han SJ, Kim TH, Cechetto J, Nam J, Ahn S, Sommer P, Liuzzi M, Lee J. Kim J, et al. Among authors: ko y. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5473-7. doi: 10.1016/j.bmcl.2014.10.007. Epub 2014 Oct 23. Bioorg Med Chem Lett. 2014. PMID: 25455487
Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents.
Kim HJ, Li Y, Zimmermann M, Lee Y, Lim HW, Leong Tan AS, Choi I, Ko Y, Lee S, Seo JJ, Seo M, Jeon HK, Cechetto J, Hoong Yam JK, Yang L, Sauer U, Jang S, Pethe K. Kim HJ, et al. Among authors: ko y. Cell Chem Biol. 2022 Aug 18;29(8):1317-1324.e5. doi: 10.1016/j.chembiol.2022.07.001. Epub 2022 Jul 27. Cell Chem Biol. 2022. PMID: 35901793 Free article.
5,776 results