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TopBP1 associates with NBS1 and is involved in homologous recombination repair.
Morishima K, Sakamoto S, Kobayashi J, Izumi H, Suda T, Matsumoto Y, Tauchi H, Ide H, Komatsu K, Matsuura S. Morishima K, et al. Among authors: kobayashi j. Biochem Biophys Res Commun. 2007 Nov 3;362(4):872-9. doi: 10.1016/j.bbrc.2007.08.086. Epub 2007 Aug 24. Biochem Biophys Res Commun. 2007. PMID: 17765870
Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination.
Ohara M, Funyu Y, Ebara S, Sakamoto Y, Seki R, Iijima K, Ohishi A, Kobayashi J, Komatsu K, Tachibana A, Tauchi H. Ohara M, et al. Among authors: kobayashi j. J Radiat Res. 2014 Jul;55(4):690-8. doi: 10.1093/jrr/rru011. Epub 2014 Mar 9. J Radiat Res. 2014. PMID: 24614819 Free PMC article.
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