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Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity.
Yagmur E, Koch A, Haumann M, Kramann R, Trautwein C, Tacke F. Yagmur E, et al. Clin Biochem. 2012 Jan;45(1-2):82-7. doi: 10.1016/j.clinbiochem.2011.10.016. Epub 2011 Nov 4. Clin Biochem. 2012. PMID: 22085533
DESIGN AND METHODS: We analyzed serum HA levels in 164 critically ill patients at a medical ICU and 61 healthy controls, with respect to organ dysfunction, systemic inflammation and mortality. ...
DESIGN AND METHODS: We analyzed serum HA levels in 164 critically ill patients at a medical ICU and 61 healthy controls, with respect …
Hyperglycemia at admission to the intensive care unit is associated with elevated serum concentrations of interleukin-6 and reduced ex vivo secretion of tumor necrosis factor-alpha.
Wasmuth HE, Kunz D, Graf J, Stanzel S, Purucker EA, Koch A, Gartung C, Heintz B, Gressner AM, Matern S, Lammert F. Wasmuth HE, et al. Crit Care Med. 2004 May;32(5):1109-14. doi: 10.1097/01.ccm.0000124873.05080.78. Crit Care Med. 2004. PMID: 15190958
SETTING: Medical intensive care unit of a university hospital. PATIENTS: Patients were 189 consecutive critically ill patients in the medical intensive care unit. ...Furthermore, elevated glucose concentrations at admission are associated with increased intensive care unit …
SETTING: Medical intensive care unit of a university hospital. PATIENTS: Patients were 189 consecutive critically ill patients in the …
High C5a levels are associated with increased mortality in sepsis patients--no enhancing effect by actin-free Gc-globulin.
Gressner OA, Koch A, Sanson E, Trautwein C, Tacke F. Gressner OA, et al. Clin Biochem. 2008 Aug;41(12):974-80. doi: 10.1016/j.clinbiochem.2008.05.005. Epub 2008 May 27. Clin Biochem. 2008. PMID: 18538666
BACKGROUND: Immune paralysis of phagocytic cells due to excess of the complement activation product C5a has been proposed as a critical pathomechanism in sepsis. ...C5a serum level was a prognostic parameter in patients with sepsis: High C5a levels were associated w …
BACKGROUND: Immune paralysis of phagocytic cells due to excess of the complement activation product C5a has been proposed as a critic …
Longitudinal monocyte human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis.
Berres ML, Schnyder B, Yagmur E, Inglis B, Stanzel S, Tischendorf JJ, Koch A, Winograd R, Trautwein C, Wasmuth HE. Berres ML, et al. Liver Int. 2009 Apr;29(4):536-43. doi: 10.1111/j.1478-3231.2008.01870.x. Epub 2008 Sep 15. Liver Int. 2009. PMID: 18795898
BACKGROUND: Critical illness in cirrhotic patients is associated with a poor prognosis and increased susceptibility to infections. ...CONCLUSIONS: Here we establish the relative HLA-DR expression (admission/day 3) as a prognostic marker for ICU mortality in critical …
BACKGROUND: Critical illness in cirrhotic patients is associated with a poor prognosis and increased susceptibility to infections. .. …
Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients.
Koch A, Gressner OA, Sanson E, Tacke F, Trautwein C. Koch A, et al. Crit Care. 2009;13(3):R95. doi: 10.1186/cc7925. Epub 2009 Jun 19. Crit Care. 2009. PMID: 19545363 Free PMC article.
For all critically ill patients, a correlation to the homeostasis model assessment index of insulin resistance (HOMA-IR) was shown. ...Moreover, resistin could potentially serve as a prognostic biomarker in non-sepsis critically ill patients....
For all critically ill patients, a correlation to the homeostasis model assessment index of insulin resistance (HOMA-IR) was shown. . …
Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis.
Koch A, Sanson E, Helm A, Voigt S, Trautwein C, Tacke F. Koch A, et al. Crit Care. 2010;14(3):R94. doi: 10.1186/cc9029. Epub 2010 May 25. Crit Care. 2010. PMID: 20500817 Free PMC article.
In order to identify possible pathogenic functions of ghrelin in critically ill patients and human sepsis from a clinical point of view, we aimed at analyzing ghrelin serum concentrations in a large cohort of well characterized patients with critical illness. ...Hig …
In order to identify possible pathogenic functions of ghrelin in critically ill patients and human sepsis from a clinical point of vi …
Relevance of serum leptin and leptin-receptor concentrations in critically ill patients.
Koch A, Weiskirchen R, Zimmermann HW, Sanson E, Trautwein C, Tacke F. Koch A, et al. Mediators Inflamm. 2010;2010:473540. doi: 10.1155/2010/473540. Epub 2010 Sep 7. Mediators Inflamm. 2010. PMID: 20871818 Free PMC article.
Our study indicates a functional role of leptin in the pathogenesis of severe illness and emphasizes the impact of complex metabolic alterations on the clinical outcome of critically ill patients....
Our study indicates a functional role of leptin in the pathogenesis of severe illness and emphasizes the impact of complex metabolic …
Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation.
Koch A, Weiskirchen R, Sanson E, Zimmermann HW, Voigt S, Dückers H, Trautwein C, Tacke F. Koch A, et al. Crit Care. 2010;14(5):R179. doi: 10.1186/cc9285. Epub 2010 Oct 8. Crit Care. 2010. PMID: 20932285 Free PMC article.
METHODS: We conducted a prospective single-center study of serum RBP4 concentrations in critically ill patients. One hundred twenty-three patients (85 with sepsis, 38 without sepsis) were studied at admission to a medical intensive care unit (ICU) before initiation …
METHODS: We conducted a prospective single-center study of serum RBP4 concentrations in critically ill patients. One hundred twenty-t …
Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients.
Koch A, Voigt S, Sanson E, Dückers H, Horn A, Zimmermann HW, Trautwein C, Tacke F. Koch A, et al. Crit Care. 2011;15(1):R45. doi: 10.1186/cc10007. Epub 2011 Jan 31. Crit Care. 2011. PMID: 21281508 Free PMC article.
INTRODUCTION: C-type natriuretic peptide (CNP) is a paracrine molecule which is mainly synthesized in the vasculature. High levels have been reported in sepsis, and CNP has been proposed as a biomarker predicting sepsis in traumatized patients. ...Low initial NT-pro …
INTRODUCTION: C-type natriuretic peptide (CNP) is a paracrine molecule which is mainly synthesized in the vasculature. High levels ha …
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