Koch T - Search Results

1

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality.

Elmén J, Thonberg H, Ljungberg K, Frieden M, Westergaard M, Xu Y, Wahren B, Liang Z, Ørum H, Koch T, Wahlestedt C. Elmén J, et al. Among authors: koch t. Nucleic Acids Res. 2005 Jan 14;33(1):439-47. doi: 10.1093/nar/gki193. Print 2005. Nucleic Acids Res. 2005. PMID: 15653644 Free PMC article.

2

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

Frieden M, Christensen SM, Mikkelsen ND, Rosenbohm C, Thrue CA, Westergaard M, Hansen HF, Ørum H, Koch T. Frieden M, et al. Among authors: koch t. Nucleic Acids Res. 2003 Nov 1;31(21):6365-72. doi: 10.1093/nar/gkg820. Nucleic Acids Res. 2003. PMID: 14576324 Free PMC article.

3

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T. Straarup EM, et al. Among authors: koch t. Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8. Nucleic Acids Res. 2010. PMID: 20615897 Free PMC article.

4

Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.

Frieden M, Hansen HF, Koch T. Frieden M, et al. Among authors: koch t. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1041-3. doi: 10.1081/NCN-120022731. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565339

5

On the in vitro and in vivo properties of four locked nucleic acid nucleotides incorporated into an anti-H-Ras antisense oligonucleotide.

Fluiter K, Frieden M, Vreijling J, Rosenbohm C, De Wissel MB, Christensen SM, Koch T, Ørum H, Baas F. Fluiter K, et al. Among authors: koch t. Chembiochem. 2005 Jun;6(6):1104-9. doi: 10.1002/cbic.200400419. Chembiochem. 2005. PMID: 15861430

6

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

Stein CA, Hansen JB, Lai J, Wu S, Voskresenskiy A, Høg A, Worm J, Hedtjärn M, Souleimanian N, Miller P, Soifer HS, Castanotto D, Benimetskaya L, Ørum H, Koch T. Stein CA, et al. Among authors: koch t. Nucleic Acids Res. 2010 Jan;38(1):e3. doi: 10.1093/nar/gkp841. Epub 2009 Oct 23. Nucleic Acids Res. 2010. PMID: 19854938 Free PMC article.

7

Quantum mechanical studies of DNA and LNA.

Koch T, Shim I, Lindow M, Ørum H, Bohr HG. Koch T, et al. Nucleic Acid Ther. 2014 Apr;24(2):139-48. doi: 10.1089/nat.2013.0465. Epub 2014 Feb 3. Nucleic Acid Ther. 2014. PMID: 24491259 Free PMC article.

8

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T. Lindholm MW, et al. Among authors: koch t. Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22. Mol Ther. 2012. PMID: 22108858 Free PMC article.

9

Electronic Structures of LNA Phosphorothioate Oligonucleotides.

Bohr HG, Shim I, Stein C, Ørum H, Hansen HF, Koch T. Bohr HG, et al. Among authors: koch t. Mol Ther Nucleic Acids. 2017 Sep 15;8:428-441. doi: 10.1016/j.omtn.2017.05.011. Epub 2017 Jun 1. Mol Ther Nucleic Acids. 2017. PMID: 28918042 Free PMC article.

10

Detection of thymine [2+2] photodimer repair in DNA: selective reaction of KMnO4.

Ramaiah D, Koch T, Orum H, Schuster GB. Ramaiah D, et al. Among authors: koch t. Nucleic Acids Res. 1998 Sep 1;26(17):3940-3. doi: 10.1093/nar/26.17.3940. Nucleic Acids Res. 1998. PMID: 9705501 Free PMC article.

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