Koch T - Search Results

1

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

Stein CA, Hansen JB, Lai J, Wu S, Voskresenskiy A, Høg A, Worm J, Hedtjärn M, Souleimanian N, Miller P, Soifer HS, Castanotto D, Benimetskaya L, Ørum H, Koch T. Stein CA, et al. Among authors: koch t. Nucleic Acids Res. 2010 Jan;38(1):e3. doi: 10.1093/nar/gkp841. Epub 2009 Oct 23. Nucleic Acids Res. 2010. PMID: 19854938 Free PMC article.

2

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T. Straarup EM, et al. Among authors: koch t. Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8. Nucleic Acids Res. 2010. PMID: 20615897 Free PMC article.

3

Silencing of gene expression by gymnotic delivery of antisense oligonucleotides.

Soifer HS, Koch T, Lai J, Hansen B, Hoeg A, Oerum H, Stein CA. Soifer HS, et al. Among authors: koch t. Methods Mol Biol. 2012;815:333-46. doi: 10.1007/978-1-61779-424-7_25. Methods Mol Biol. 2012. PMID: 22131003

4

A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells.

Castanotto D, Lin M, Kowolik C, Wang L, Ren XQ, Soifer HS, Koch T, Hansen BR, Oerum H, Armstrong B, Wang Z, Bauer P, Rossi J, Stein CA. Castanotto D, et al. Among authors: koch t. Nucleic Acids Res. 2015 Oct 30;43(19):9350-61. doi: 10.1093/nar/gkv964. Epub 2015 Oct 3. Nucleic Acids Res. 2015. PMID: 26433227 Free PMC article.

5

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells.

Castanotto D, Lin M, Kowolik C, Koch T, Hansen BR, Oerum H, Stein CA. Castanotto D, et al. Among authors: koch t. Mol Ther. 2016 Jun;24(6):1117-1125. doi: 10.1038/mt.2016.54. Epub 2016 Mar 10. Mol Ther. 2016. PMID: 26961407 Free PMC article.

6

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality.

Elmén J, Thonberg H, Ljungberg K, Frieden M, Westergaard M, Xu Y, Wahren B, Liang Z, Ørum H, Koch T, Wahlestedt C. Elmén J, et al. Among authors: koch t. Nucleic Acids Res. 2005 Jan 14;33(1):439-47. doi: 10.1093/nar/gki193. Print 2005. Nucleic Acids Res. 2005. PMID: 15653644 Free PMC article.

7

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

Frieden M, Christensen SM, Mikkelsen ND, Rosenbohm C, Thrue CA, Westergaard M, Hansen HF, Ørum H, Koch T. Frieden M, et al. Among authors: koch t. Nucleic Acids Res. 2003 Nov 1;31(21):6365-72. doi: 10.1093/nar/gkg820. Nucleic Acids Res. 2003. PMID: 14576324 Free PMC article.

8

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.

Hagedorn PH, Yakimov V, Ottosen S, Kammler S, Nielsen NF, Høg AM, Hedtjärn M, Meldgaard M, Møller MR, Orum H, Koch T, Lindow M. Hagedorn PH, et al. Among authors: koch t. Nucleic Acid Ther. 2013 Oct;23(5):302-10. doi: 10.1089/nat.2013.0436. Epub 2013 Aug 16. Nucleic Acid Ther. 2013. PMID: 23952551 Free PMC article.

9

Electronic Structures of LNA Phosphorothioate Oligonucleotides.

Bohr HG, Shim I, Stein C, Ørum H, Hansen HF, Koch T. Bohr HG, et al. Among authors: koch t. Mol Ther Nucleic Acids. 2017 Sep 15;8:428-441. doi: 10.1016/j.omtn.2017.05.011. Epub 2017 Jun 1. Mol Ther Nucleic Acids. 2017. PMID: 28918042 Free PMC article.

10

Detection of thymine [2+2] photodimer repair in DNA: selective reaction of KMnO4.

Ramaiah D, Koch T, Orum H, Schuster GB. Ramaiah D, et al. Among authors: koch t. Nucleic Acids Res. 1998 Sep 1;26(17):3940-3. doi: 10.1093/nar/26.17.3940. Nucleic Acids Res. 1998. PMID: 9705501 Free PMC article.

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