Koch T - Search Results

1

Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S. Obad S, et al. Among authors: koch t. Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786. Nat Genet. 2011. PMID: 21423181 Free PMC article.

2

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T. Straarup EM, et al. Among authors: koch t. Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8. Nucleic Acids Res. 2010. PMID: 20615897 Free PMC article.

3

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T. Lindholm MW, et al. Among authors: koch t. Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22. Mol Ther. 2012. PMID: 22108858 Free PMC article.

4

Quantum mechanical studies of DNA and LNA.

Koch T, Shim I, Lindow M, Ørum H, Bohr HG. Koch T, et al. Nucleic Acid Ther. 2014 Apr;24(2):139-48. doi: 10.1089/nat.2013.0465. Epub 2014 Feb 3. Nucleic Acid Ther. 2014. PMID: 24491259 Free PMC article.

5

Managing the sequence-specificity of antisense oligonucleotides in drug discovery.

Hagedorn PH, Hansen BR, Koch T, Lindow M. Hagedorn PH, et al. Among authors: koch t. Nucleic Acids Res. 2017 Mar 17;45(5):2262-2282. doi: 10.1093/nar/gkx056. Nucleic Acids Res. 2017. PMID: 28426096 Free PMC article. Review.

6

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.

Hagedorn PH, Pontoppidan M, Bisgaard TS, Berrera M, Dieckmann A, Ebeling M, Møller MR, Hudlebusch H, Jensen ML, Hansen HF, Koch T, Lindow M. Hagedorn PH, et al. Among authors: koch t. Nucleic Acids Res. 2018 Jun 20;46(11):5366-5380. doi: 10.1093/nar/gky397. Nucleic Acids Res. 2018. PMID: 29790953 Free PMC article.

7

SPC3042: a proapoptotic survivin inhibitor.

Hansen JB, Fisker N, Westergaard M, Kjaerulff LS, Hansen HF, Thrue CA, Rosenbohm C, Wissenbach M, Orum H, Koch T. Hansen JB, et al. Among authors: koch t. Mol Cancer Ther. 2008 Sep;7(9):2736-45. doi: 10.1158/1535-7163.MCT-08-0161. Mol Cancer Ther. 2008. PMID: 18790754 Free article.

8

Targeting Repeated Regions Unique to a Gene Is an Effective Strategy for Discovering Potent and Efficacious Antisense Oligonucleotides.

Pedersen L, Hagedorn P, Vikeså J, Karlsen ST, Særmark P, Koch T, Lindow M. Pedersen L, et al. Among authors: koch t. Mol Ther Nucleic Acids. 2020 Mar 6;19:124-131. doi: 10.1016/j.omtn.2019.10.040. Epub 2019 Nov 15. Mol Ther Nucleic Acids. 2020. PMID: 31846799 Free PMC article.

9

Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.

Frieden M, Hansen HF, Koch T. Frieden M, et al. Among authors: koch t. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1041-3. doi: 10.1081/NCN-120022731. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565339

10

Effect of LNA modifications on small molecule binding to nucleic acids.

Marin V, Hansen HF, Koch T, Armitage BA. Marin V, et al. Among authors: koch t. J Biomol Struct Dyn. 2004 Jun;21(6):841-50. doi: 10.1080/07391102.2004.10506974. J Biomol Struct Dyn. 2004. PMID: 15107006

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